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| 祛银汤治疗血热证银屑病临床观察及其对外周血OPN和VEGF表达的影响 | |
| 引用本文： | 张春红,杜锡贤,张春敏.祛银汤治疗血热证银屑病临床观察及其对外周血OPN和VEGF表达的影响[J].中国皮肤性病学杂志,2011,25(3). |
| 作者姓名： | 张春红 杜锡贤 张春敏 |
| 作者单位： | 1. 山东大学第二医院皮肤科,山东,济南,250033;山东中医药大2008级,山东,济南,250307 2. 山东中医药大学附属医院皮肤科,山东,济南,250011 3. 山东大学第二医院皮肤科,山东,济南,250033 |
| 基金项目： | 山东省中医药科学技术研究项目资助，山东省科技攻关项目资助 |
| 摘 要： | 目的观察祛银汤治疗血热证型寻常性银屑病的临床疗效及其对外周血清中骨桥蛋白(osteopontin,OPN)和血管内皮细胞生长因子(vascular endothelial growth factor,VEGF)的影响。方法共入选24例血热证型寻常性银屑病患者,观察其治疗前、后皮损面积和严重性指数(psoriasis area and severity index,PA-SI)评分及中医症状评分的变化,并采用酶联免疫吸附试验(ELISA)检测患者治疗前、后外周血中OPN和VEGF的表达。结果祛银汤治疗8周后有效率为79.17%;治疗后PASI评分和各中医症状均较治疗前明显改善。治疗前银屑病患者外周血清OPN和VEGF表达明显升高,治疗后明显降低,差异均有统计学意义(P均<0.05),且OPN与PASI评分呈正相关关系(r=0.44,P<0.05)。结论血热证型寻常性银屑病患者OPN和VEGF异常表达,祛银汤可纠正外周血中异常的OPN和VEGF表达水平。 |
| 关 键 词： | 银屑病 血热证 祛银汤 骨桥蛋白 血管内皮细胞生长因子 |
Clinical Study of Traditional Chinese Medical Herbs(QuYin Tang)in the Treatment of Psoriasis Vulgaris and the Influence on OPN and VEGF in Serum |
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| ZHANG Chun-hong,DU Xi-xian,ZHANG Chun-min.Clinical Study of Traditional Chinese Medical Herbs(QuYin Tang)in the Treatment of Psoriasis Vulgaris and the Influence on OPN and VEGF in Serum[J].The Chinese Journal of Dermatovenereology,2011,25(3). | |
| Authors: | ZHANG Chun-hong DU Xi-xian ZHANG Chun-min |
| Institution: | ZHANG Chun-hong1,2,DU Xi-xian3,ZHANG Chun-min1 ( 1. Department of Dermatology,the Second Hospital of Shandong University,Jinan250033,China,2. Shandong University of Traditional Chinese Medicine,Jinan 250307,3. Department of Dermatology,the Affiliated Hospital of Shandong University of Traditional Chinese Medicine,Jinan 250011,China ) |
| Abstract: | Objective To observe the clinical effects and explore the mechanism of traditional Chinese medical herbs ( QuYin Tang) in treating psoriasis vulgaris of blood-heat syndrome type. Methods Twenty-four patients with psoriasis enrolled in this study were treated with QuYin Tang. The changes of psoriasis area,severity index ( PASI) scores and other syndromes were observed. The levels of osteopontin ( OPN) and vascular endothelial growth factor ( VEGF) in serum of psoriastic patients before and after treatment we... |
| Keywords: | Psoriasis vulgris Blood-heat syndrome type Traditional Chinese medical herbs ( QuYin Tang) Osteopontin Vascular endothelial growth factor |
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