| 盐酸小檗碱联合抗真菌药物对红色毛癣菌的体外药敏实验 |
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| 引用本文： | 佟盼琢,王冰心,冯琴,杨晓亮,杨云,谢红霞.盐酸小檗碱联合抗真菌药物对红色毛癣菌的体外药敏实验[J].中国皮肤性病学杂志,2011,25(5). |
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| 作者姓名： | 佟盼琢 王冰心 冯琴 杨晓亮 杨云 谢红霞 |
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| 作者单位： | 河北医科大学第二医院皮肤性病科,河北,石家庄,050000 |
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| 摘 要： | 目的观察盐酸小檗碱联合不同浓度抗真菌药物对红色毛癣菌的体外抗菌活性。方法参照美国临床实验室标准化研究所(CLSI)颁布的M38-A2方案和相关文献对临床分离的30株红色毛癣菌进行体外药敏实验。其中盐酸小檗碱的MIC值定义为与生长对照相比,肉眼观察出现80%生长抑制的最低药物浓度。采用分数抑菌浓度(FIC)评定两药联合效果。FIC≤0.5,两药为协同作用;0.54,两药为拮抗作用。结果盐酸小檗碱和不同浓度伊曲康唑联合,主要为无关作用。盐酸小檗碱和不同浓度特比奈芬、伏立康唑联合,均为拮抗作用。16.0μg/mL氟康唑组与盐酸小檗碱联合时FIC≤0.5所占比例为83.33%,协同作用最强;2.0～8.0μg/mL卡泊芬净组与盐酸小檗碱联合时,FIC≤0.5所占比例最高,均为63.33%,协同作用最强,差异均有统计学意义(P均<0.05)。结论盐酸小檗碱与高浓度氟康唑、卡泊芬净联合,体外对红色毛癣菌有较强的协同作用。
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| 关 键 词： | 盐酸小檗碱 抗真菌药物 红色毛癣菌 药敏试验 |
Susceptibility Test by Berberine Hydrochloride Combined with Antifungal Agents Against Trichophyton Rubrum in Vitro |
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| TONG Pan-zhuo,WANG Bing-xin,FENG Qin,YANG Xiao-liang,YANG Yun,XIE Hong-xia.Susceptibility Test by Berberine Hydrochloride Combined with Antifungal Agents Against Trichophyton Rubrum in Vitro[J].The Chinese Journal of Dermatovenereology,2011,25(5). |
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| Authors: | TONG Pan-zhuo WANG Bing-xin FENG Qin YANG Xiao-liang YANG Yun XIE Hong-xia |
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| Institution: | TONG Pan-zhuo,WANG Bing-xin,FENG Qin,YANG Xiao-liang,YANG Yun,XIE Hong-xia(Department of Dermatology,Second Hospital of Hebei Medical University,Shijiazhuang 050000,China) |
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| Abstract: | Objective To explore the antifungal activity of Berberine hydrochloride combined with different concentrations of antifungal agents against trichophyton rubrum in vitro.Methods According to the program of M38-A2 from the United States National Clinical and Laboratory Standards Institute(CLSI) and relevant literatures,susceptibility test was done with 30 clinical isolates of trichophyton rubrum in vitro.The MIC value of Berberine was defined as that growth compared with the naked eye control showing appear 8... |
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| Keywords: | Berberine hydrochloride Antifungal agents Trichophyton rubrum Drug sensitivity test |
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