| 永生化人毛乳头细胞系体内诱导毛囊的形成 |
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| 引用本文： | 刘官智,伍津津. 永生化人毛乳头细胞系体内诱导毛囊的形成[J]. 中国皮肤性病学杂志, 2011, 25(3) |
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| 作者姓名： | 刘官智 伍津津 |
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| 作者单位： | 1. 四川省自贡市第四人民医院皮肤科,四川自贡,643000
2. 第三军医大学大坪医院野战外科研究所皮肤科,重庆,400042 |
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| 摘 要： | 目的研究永生化人毛乳头细胞(DPC)系DPC-hTERT在体内诱导毛囊形成的能力。方法将第30代DPC-hTERT与刚分离的毛囊上皮细胞混合后直接注射到裸鼠背部皮下,观察毛囊形成情况。结果 DPC-hTERT与刚分离的毛囊上皮细胞混合后注射到裸鼠背部皮下后,可见毛囊样结构形成,且此结构表达毛囊特有的角蛋白。结论 DPC-hTERT具有正常DPC的功能,具备在体内诱导毛囊样结构的能力。
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| 关 键 词： | 毛乳头细胞 永生化 毛囊 诱导 |
The Formation of Hair Follicle induced by Immortalized Human Dermal Papilla Cell Line in viva |
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| LIU Guan-zhi,WU Jin-jin. The Formation of Hair Follicle induced by Immortalized Human Dermal Papilla Cell Line in viva[J]. The Chinese Journal of Dermatovenereology, 2011, 25(3) |
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| Authors: | LIU Guan-zhi WU Jin-jin |
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| Affiliation: | LIU Guan-zhi1,WU Jin-jin2 (1.Department of Dermatology,FourthPeople's Hospital of ZigongCity,Zigong643000,China,2.Department of Dermatology,Research Institute of Field Surgery,Daping Hospital,Third Military Medical University,Chongqing 400042,China) |
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| Abstract: | Objective To investigate the hair follicle-inducing ability of the immortalized human dermal papilla cell ( DPC) line DPC-hTERT in vivo. Methods The DPC-hTERT at passage30 and the fresh isolated hair follicle epithelial cells were co-injected subcutaneously into nude mice. The formation of hair follicle was observed. Results Co-injected the DPC-hTERT cells and fresh isolated hair follicle epithelial cells into nude mice formed hair follicle-like structure which expressed the hair follicle-specific keratin. ... |
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| Keywords: | Dermal papilla cells Immortalization Hair follicle Induce |
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