伊贝沙坦联合培哚普利治疗充血性心力衰竭疗效观察

目的 :探讨伊贝沙坦联合培哚普利治疗慢性充血性心力衰竭 (CHF)的临床疗效。方法 :6 4例CHF患者随机分成治疗组和对照组。治疗组 34例给予伊贝沙坦 15 0mg/d ,培哚普利 4mg/d ;对照组给予培哚普利 4mg/d及安慰剂治疗。两组基础治疗类同 ,疗程 6个月。观察治疗前后两组患者的临床症状 ,超声心动图心功能指标 ,6min步行距离的变化及不良反应。结果 :治疗后 ,治疗组临床总有效率为 88.2 4 % ,对照组总有效率为80 .0 0 % ;两组治疗前后相比左室射血分数 (LVEF)、每搏量、心脏指数 (CI)、6min步行距离均有显著改善 (P <0 .0 1) ,治疗组LVEF、CI及 6min步行距离的改善优于对照组。结论 :伊贝沙坦联合培哚普利治疗CHF可以增强疗效。

The clinical efficacy of ibesartan combined with perindopril on the treatment of congestive heart failure

Objective:To evaluate the clinical therapeutic efficacy of irbesartan combined with perindopril on the treatment of congestive heart failure (CHF ).Methods:Using random and single blind contrast during the period of 6 month, we divided 64 patients with CHF into the treatment group (n=34 ) and the control group (n=30). The clinical therapeutic efficacy, LVEF, SV, CI, 6min walk trial and adverse reactions were analyzed.Results:The clinical prognosis and LVEF, SV, CI, 6 min walk trail of the patient in the two group were all significantly ameliorated compared with those of the patient before treatment (P< 0.01 ), Improvement of symptom in treatment group were better than that in control group.Conclusion:Irbesartan combined with perindopril have obvious effects on treating patient with CHF.