| 脑缺血时谷氨酸释放机制 |
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| 引用本文： | 梅和珊,王永利.脑缺血时谷氨酸释放机制[J].中国药理学通报,2005,21(4):393-396. |
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| 作者姓名： | 梅和珊 王永利 |
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| 作者单位： | 河北医科大学药理学教研室,河北,石家庄,050017 |
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| 摘 要： | 谷氨酸是中枢神经系统主要的兴奋性神经递质,在脑缺血造成的神经元损伤过程中发挥重要作用。脑缺血时多种机制参与了谷氨酸释放的的调节,如Ca2+依赖性的出胞式释放、谷氨酸转运体调节的释放、水肿诱发的释放和受体调节的释放等。本文根据现有的文献资料,综述了脑缺血时谷氨酸释放机制。
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| 关 键 词： | 脑缺血 谷氨酸 γ氨基丁酸受体 谷氨酸转运体 代谢型谷氨酸受体 胱氨酸谷氨酸转运体 |
| 文章编号： | 1001-1978(2005)04-0393-04 |
| 修稿时间： | 2004年10月22 |
The mechanisms of glutamate release in cerebral ischemia |
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| MEI He-shan,WANG Yong-li.The mechanisms of glutamate release in cerebral ischemia[J].Chinese Pharmacological Bulletin,2005,21(4):393-396. |
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| Authors: | MEI He-shan WANG Yong-li |
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| Abstract: | Glutamate is a major excitatory neurotransmitter in the central nervous system(CNS)and plays an important role in neuronal damage induced by cerebral ischemia. Several mechanisms contribute to modulation of glutamate release during cerebral ischemia, such as vesicular release dependent on calcium, release by reversed operation of glutamate transporters, release through swelling-activated anion channel and receptor-modulating release, etc. This review addresses the mechanisms of glutamate release during cerebral ischemia. |
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| Keywords: | cerebral ischemia γ-aminobutyric acid receptors glutamate glutamate transporter metabotropic glutamate receptors cystine-glutamate exchanger |
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