临床评分方法对急性肺栓塞诊断价值的研究

目的 对疑诊急性肺栓塞的患者进行临床分析,以判断临床评分方法对肺栓塞的诊断价值.方法 对疑诊急性肺栓塞的259例患者临床资料进行回顾性分析,采用Geneva评分、Wells评分、SYSU评分将患者罹患肺栓塞的可能性分为低、中、高三个等级,并与肺栓塞金标准确诊情况进行对比,判断三种肺栓塞评分方法的准确性和临床价值.结果应用三种临床评分方法评估低度可能患者占43.9%～52.5%,中度可能患者占38.0%～42.1%.高度可能患者占9.5%～14.0%,而急性肺栓寒的发生率低度可能为6.2%～14.4%,中度可能为65.9%～76.2%,高度可能为88.5%～90.5%.若以低度可能排除肺栓塞,则SYSU评分在低度可能中漏诊率最低(P<0.05),Geneva评分在中度可能中肺栓塞的诊断率最高(P<0.05),而在高度可能中三种临床评分方法一样准确(P>0.05).研究还发现结合D-二聚体测定(以D-二聚体<500μg/L排除肺栓塞),可降低低度可能的漏诊率.结论 临床评分方法能对罹患肺栓塞的可能性做出预测,三种临床评分方法有相似的准确性,但应用范围不同,应根据不同患者选择相应的临床评分方法.

Diagnostic value of me clinical grading methods in acute pulmonary embolism

Objective To evaluate the significance of clinical grading methods in acute pulmonary embolism (APE). Methods Clinical data of 259 patients suspected APE were retrospectively analyzed. The clinical probability was classified into low, intermediate and high grade by the Geneva score, the Wells score and the SYSU score. The result was contrasted with gold standard. Results Through the three, methods, pa-tients were classified into low pmbability (43.9%-52.5%), intermediate probability (38.0%-42.1%) and high probability (9.5%-14.0%), and the actual frequencies of APE in each category were 6.2%-14.4% in low probability, 65.9%-76.2% in intermediate probability, 88.5%-90.5% in high probability. The SYSU score had the lowest rate of missed diagnosis in low probability (P<0.05 ).The Geneva score was the most accurate in predicting the intermediate probability (P<0.05). But in high probahility, three prediction rules had no significant difference (P>0.05). Combined with D--dimer test, the rote of missed diagnosis in low probability can be lowered. Conclusions The clinical grading methods can predict the clinical probability of APE. It exists similar accuracy, but has different scope of application. Clinical doctor should choose the ap-propriate grading methods in different patients.