| 对糖尿病合并高血压患者血浆内皮素－1和降钙素基因相关肽改变的观察 |
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| 引用本文： | 王立,邢维常,盛树力,张人玲,侯鹏,寿吉萍,张淑敏,钱荣立.对糖尿病合并高血压患者血浆内皮素－1和降钙素基因相关肽改变的观察[J].北京医学,1994(1). |
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| 作者姓名： | 王立 邢维常 盛树力 张人玲 侯鹏 寿吉萍 张淑敏 钱荣立 |
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| 作者单位： | 首都医学院宣武医院内分泌科 |
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| 摘 要： | 为研究糖尿病合并高血压的发病机制，本文测定和比较了１９例血压正常的非胰岛素依赖型糖尿病（ＮＩＤＤＭ）病人，１１例单纯高血压病人，１２例ＮＩＤＤＭ合并高血压病人和１４例正常人的血浆内皮素－１（ＥＴ－１）和降钙素基因相关肽（ＣＧＲＰ）水平。结果发现：三组病人的ＥＴ－１水平均显著高于对照组，且呈依次上升趋势，而单纯高血压病组和糖尿病合并高血压组的ＣＧＲＰ水平均明显低于对照组，提示糖尿病合并高血压血浆ＥＴ－１升高，ＣＧＲＰ减低可能是糖尿病合并高血压的发病因素之一。
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| 关 键 词： | 糖尿病合并高血压，ET－1，CGRP |
Investigation On Plasma Concentrations of ET-1 And CGRP In Diabetics Complicated With Hypertension |
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| Wang Li,et al.Investigation On Plasma Concentrations of ET-1 And CGRP In Diabetics Complicated With Hypertension[J].Beijing Medical Journal,1994(1). |
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| Authors: | Wang Li |
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| Institution: | Endocrine of Xuanwu Hospital Attached to the Capital Institute of Medicine |
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| Abstract: | In order to study the pathogenic mechanism of diabetics complicated with hypertension, we investigated and compared the plasma concentrations of ET-1 and CGRP in 19 cases of INDDM patients with normal blood pressure (Group 1),11 cases of simple hypertensive patients without NIDDM (Group 2), 12cases of INDDM patients complicated with hypertension(Group 4) and 14 cases of normal persom. The results showed that the concentrations of ET-1 of the first three groups were significantly higher than those of control groups and showed an ascending tendency according to the sequence.But the concentrations of CGRP of simple hypertension group and simple NIDDM group were much lower than those of controller. The results indicate that high plasma concentration of ET-1 and low concentration of CGRP may act the pathogenic factors predisposing occurrence of diabetics complicated with hypertension. |
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| Keywords: | Diabetic with Hypertension ET-1 CGRP |
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