| 环氧合酶-2与肿瘤的放射治疗 |
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| 引用本文： | 卢鑫,朱兆峰,肖宝荣. 环氧合酶-2与肿瘤的放射治疗[J]. 国际肿瘤学杂志, 2009, 36(12). DOI: 10.3760/cma.j.issn.1673-422X.2009.12.010 |
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| 作者姓名： | 卢鑫 朱兆峰 肖宝荣 |
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| 作者单位： | 山东泰安市肿瘤医院放疗科,271000;山东泰安市肿瘤医院放疗科,271000;山东泰安市肿瘤医院放疗科,271000 |
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| 摘 要： | 环氧合酶-2(COX-2)在多种恶性肿瘤组织中呈高表达,其表达与肿瘤放疗密切相关,通过放射线对COX-2的诱导表达,可以降低肿瘤对放疗的敏感性,预后较差.临床上可根据检测COX-2蛋白的表达水平来评估肿瘤患者对放疗是否抵抗,以预测患者的放疗效应,并据此制定个体化治疗方案.
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| 关 键 词： | 环氧合酶-2 肿瘤 放射疗法 |
Cyclooxygenase-2 and tumor radiotherapy |
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| Abstract: | Cyclooxygenase-2(COX-2) is highly expressed in varieties of malignant tumors,which is closely related to tumor radiotherapy. The induction of COX-2 by radioactive ray can decrease tumor radiosensitivity,and the prognosis of patients is poor. We can evaluate radiotherapy resistance by detecting the expression of COX-2 protein,and then to predict radiotherapy effect,finally to formulate individualized treatment plan. |
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| Keywords: | Cyclooxygenase-2 Neoplasms Radiotherapy |
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