他汀类药物对血清甘油三酯的作用

为观察他汀类药物对血清甘油三酯的作用及治疗前基础血清甘油三酯水平对其治疗作用的影响，本文分析了１９９４－１９９８年期间进行的辛伐他汀和洛伐他汀两项中心临床药物试验。治疗前血清总胆固醇≥５．９８ｍｍｏｌ／Ｌ，甘油三酯≤４．５２ｍｍｏｌ／Ｌ，按治疗前基础血清甘油三酯水平分组：辛伐他汀试验者１６６例，口服辛伐他汀１０ｍｇ／ｄ；洛伐他汀试验者１４６例，口服洛伐他汀２０ｍｇ／ｄ疗程均为８周。

Effect of Statins on Triglyceride in Patients with Hyperlipidemia

Aim To evaluate the effect of statins on serum triglyceride in patients with hyperlipidemia, and whether the effect is related to baseline triglyceride levels. Methods The data analysed were originated from 2 separate multicenter clinical trials with similar designs. Baseline total cholesterol lecels was more than 5.98 mmol/L, and baseline triglyceride lecels was less than 4.52 mmol/L. The patients were grouped by baseline triglyceride levels. 166 patients had participated in Simvastatin Clinical Trial with simvastatin 10 mg once daily for 8 weeks. 146 patients had participated in Lovastatin Clinical Trial with lovastatin 20 mg once daily for 8 weeks. Results It showed that the higher the baseline triglyceride levels were, the more effective the simvastatin or lovastatin was in reducing serum triglyceride lecels. A positive correlation was found between baseline triglyceride levels and effects of simvastatin (r=0.3155, P<0.01) and lovastatin (r=0.3341, P<0.01) in reducing serum triglyceride lecels . Conclusions statins was effective in decreasing triglyceride levels in patients with hypertriglyceridemia. The change of reduction on triglyceride was closely related to baseline triglyceride lecels.