| 原发性高血压的易感基因 |
| |
| 引用本文： | Qiu CC,Zhou WY. 原发性高血压的易感基因[J]. 中国医学科学院学报, 2006, 28(2): 284-288 |
| |
| 作者姓名： | Qiu CC Zhou WY |
| |
| 作者单位： | 中国医学科学院,中国协和医科大学,基础医学研究所医学分子生物学国家重点实验室,北京,100005 |
| |
| 摘 要： | 原发性高血压(EH)是遗传因素和环境因素相互作用引发的复杂疾病,明显的家族聚集现象、同卵双生子发病一致性等研究结果,揭示了EH的多基因遗传性质。鉴定EH易感基因不仅有助于阐明其病因学,也有助于探索预防途径和研制新的治疗药物。本文主要介绍EH易感基因研究策略和已发现的基因变异;分析EH易感基因研究存在的问题和理想样本选择对成功鉴定EH易感基因的作用。
|
| 关 键 词： | 原发性高血压 遗传力 隔离人群 易感基因 |
| 文章编号： | 1000-503X（2006）02-0284-05 |
| 收稿时间： | 2005-10-19 |
| 修稿时间： | 2005-10-19 |
Susceptible genes of essential hypertension |
| |
| Qiu Chang-chun,Zhou Wen-yu. Susceptible genes of essential hypertension[J]. Acta Academiae Medicinae Sinicae, 2006, 28(2): 284-288 |
| |
| Authors: | Qiu Chang-chun Zhou Wen-yu |
| |
| Affiliation: | National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, CAMS and PUMC, Beijing 100005, China |
| |
| Abstract: | Essential hypertension (EH) is a complex multifactorial disorder with genetic and environmental factors contributing to its prevalence. The genetic features have been revealed from the significant fami- lial aggregation and the consistence among twins. Therefore,identification of EH susceptibility genes will be helpful to understand the pathophysiology of the disease,identify populations with potential risks of developing the disease,and select antihypertensive drugs. The present article introduces the search strategies of EH susceptibility genes and some genetic variants related to EH ; meanwhile,it tries to analyze the difficulties and the role for samples in identifying susceptibility genes to EH. |
| |
| Keywords: | essential hypertension heritability lsolate population susceptibility genes |
| 本文献已被 CNKI 维普 万方数据 PubMed 等数据库收录！ |
