| 不同包衣条件下银杏缓释微丸体外释放考察 |
| |
| 引用本文： | 施路,李三鸣,宋红光,刘凯,殷丹.不同包衣条件下银杏缓释微丸体外释放考察[J].沈阳药科大学学报,2005,22(3):176-180,199. |
| |
| 作者姓名： | 施路 李三鸣 宋红光 刘凯 殷丹 |
| |
| 作者单位： | 1. 沈阳药科大学,药学院,辽宁,沈阳,110016
2. 辽东学院,医学院,辽宁,丹东,118000 |
| |
| 摘 要： | 目的考察不同包衣条件下银杏缓释微丸的体外释放。方法采用单因素考察及正交设计法。结果以丙烯酸树脂EudragitRL30D和EudragitRS30D为包衣材料,质量比为4∶1,包衣增重10 % (w) ,增塑剂的用量为2 0 % (w ) ,无需熟化,可满足2 4h缓释的要求。结论包衣量、衣膜中两种丙烯酸树脂的配比和包衣温度是影响药物释放的关键因素
|
| 关 键 词： | 缓释包衣微丸 银杏提取物 丙烯酸树脂 流化床 |
| 文章编号： | 1006-2858(2005)03-0176-05 |
Studies of Ginkgo biloba extracts coated sustained-release pellets in vitro |
| |
| SHI Lu,LI San-ming,SONG Hong-guang,LIU Kai,YIN Dan.Studies of Ginkgo biloba extracts coated sustained-release pellets in vitro[J].Journal of Shenyang Pharmaceutical University,2005,22(3):176-180,199. |
| |
| Authors: | SHI Lu LI San-ming SONG Hong-guang LIU Kai YIN Dan |
| |
| Institution: | SHI Lu~1,LI San-ming~1,SONG Hong-guang~2,LIU Kai~1,YIN Dan~1 |
| |
| Abstract: | Objective To prepare Ginkgo biloba extracts coated sustained-release pellets and study the drug release under different coating conditions.Methods Single-factor design and orthogonal experiment were applied to optimize the formulation of coated sustained-release pellets.Results A satisfactory 24 h -sustained release curve can be obtained when the pellets is coated with Eudragit RL30D and RS30D under the optimized formulation and preparing conditions.Conclusions When the weight increased,proportion of two Eudragits and the coating temperature are the main factors which influence the drug release. |
| |
| Keywords: | coated sustained-release pellets Ginkgo biloba extracts Eudragit fluid-bed |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
