| 干扰花生四烯酸代谢的药物对实验性肝损伤的影响 |
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| 引用本文： | 侯艳宁,梁小莉,程桂芳.干扰花生四烯酸代谢的药物对实验性肝损伤的影响[J].解放军药学学报,1999,15(1):13-16. |
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| 作者姓名： | 侯艳宁 梁小莉 程桂芳 |
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| 作者单位： | 白求恩国际和平医院药剂科!石家庄050082(艳宁)，解放军北京医学高等专科学校!北京100071(梁晓莉，程桂芳)，中国医学科学院药物研究所!北京100050(朱秀媛) |
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| 摘 要： | 目的：研究干扰花生四烯酸（ＡＡ）代谢的药物对实验性肝损伤的影响，探讨ＡＡ代谢与肝损伤的关系。方法：选择四氯化碳（ＣＣｌ４）、醋氨酚、卡介苗加细菌脂多糖所致的小鼠肝损伤模型，以血清谷丙转氨酶（ＡＬＴ）、肝脏丙二醛（ＭＤＡ） 和谷胱甘肽（ＧＳＨ） 水平为观察生化指标，同时光镜下观察组织病理学改变。结果：影响ＡＡ代谢的磷脂酶Ａ２（ＰＬＡ２） 抑制剂氯喹，环氧酶（ＣＯ） 抑制剂阿司匹林，环氧酶及脂氧酶（ＬＯ）双酶抑制剂氟灭酸对上述三种实验性肝损伤均无明显影响。而脂氧酶抑制剂黄芩甙和白三烯（ＬＴｓ） 受体拮抗剂ＧＬ３ 对实验性肝损伤有明显的保护作用。结论：上述结果提示ＡＡ 代谢ＬＯ途径产物如ＬＴｓ 可能在肝损中起着重要作用。
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| 关 键 词： | 花生四烯酸代谢 肝损伤 氯喹 阿司匹林 氟灭酸黄芩甙 GL_3 |
| 修稿时间： | 1998-10-28 |
EFFECTS OF THE COMPOUNDS
INTERFERING WITH ARICHIDONIC ACID METABOLISM ON EXPERIMENTAL LIVER INJURY IN MICE |
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| Hou Yanning,Liang Xiaoli,Cheng Guifang,Zhu Xiuyuan Bethune International Peace Hospital,Shijiazhuang Beijing Medical College of PLA,Beijing Institute of Meteria Medica,Chinese Acadamy of Medical Sciences,Beijing.EFFECTS OF THE COMPOUNDS
INTERFERING WITH ARICHIDONIC ACID METABOLISM ON EXPERIMENTAL LIVER INJURY IN MICE[J].Pharmaceutical Journal of Chinese People's Liberation Army,1999,15(1):13-16. |
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| Authors: | Hou Yanning Liang Xiaoli Cheng Guifang Zhu Xiuyuan Bethune International Peace Hospital Shijiazhuang Beijing Medical College of PLA Beijing Institute of Meteria Medica Chinese Acadamy of Medical Sciences Beijing |
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| Institution: | Hou Yanning,Liang Xiaoli,Cheng Guifang,Zhu Xiuyuan Bethune International Peace Hospital,Shijiazhuang 050082 Beijing Medical College of PLA,Beijing 100071 Institute of Meteria Medica,Chinese Acadamy of Medical Sciences,Beijing 100050 |
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| Abstract: | AIM To investigate the effects of the compounds interfering with arichidonic acid (AA) metabolism, on the experimental liver injury,and to study the relationship between AA metabolism and liver injury.METHODS In the CCl 4, acetaminophen (APAP), BCG and lipopolysaccharide (LPS)-induced liver injury animal models, the levels of AL, MDA, GSH and the pathologic changes of liver tissues were observed and compared in animals treated with different compounds.RESULTS Baicalin,inhibitor of LO (Lipooxygenase LO) and GL 3,antagonist of LTs showed obvious protective effects against experimental liver injury, while chloroquine, inhibitor of phospholipases A 2(PLA 2), aspirin, inhibitor of (cyclooxygenase,CO), flufenamic acid, inhibitor of both CO and LO showed no liver protective effects.CONCLUTION Metabolites of LO pathway,such as (Leukotriens,LTs),may play an important role in liver injury development. |
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| Keywords: | arichidonic acid (AA) metabolism liver injury chloroquine aspirin flufenamic acid Baicalin GL 3 |
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