COVID-19-associated coagulopathy in children: A multicenter observational cohort study |
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| Authors: | Alexandra Zabeida Rochelle Winikoff Marie-Claude Pelland-Marcotte Janie Charlebois Christine Sabapathy |
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| Institution: | 1. Division of Pediatric Hematology-Oncology, Montreal Children's Hospital, McGill University Health Centre, Montreal, Québec, Canada;2. Department of Pediatric Hematology-Oncology, Centre Hospitalier Universitaire Sainte-Justine, Montreal, Québec, Canada;3. Division of Pediatric Hematology-Oncology, Centre Hospitalier Universitaire de Québec/Centre mère-enfant Soleil, Québec City, Québec, Canada;4. Division of Pediatric Hematology-Oncology, Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke, Québec, Canada |
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| Abstract: | SARS-CoV-2 infection (coronavirus disease 2019 COVID-19]) induces a stark procoagulant state, with many hospitalized adults developing thrombosis despite prophylactic anticoagulation. This study aimed to characterize hemostatic parameters and associated clinical outcomes of COVID-19, such as thrombosis and bleeding, in children and to assess thromboprophylaxis use. This multicenter observational cohort study included 79 patients aged up to 18 years admitted to all pediatric hospitals in Québec, Canada, with SARS-CoV-2 infection during a 5-month period. D-dimers were elevated in 18/19 patients (94.7%) and fibrinogen in 15/26 patients (60%). Eleven patients (13.9%) received anticoagulant thromboprophylaxis. One thrombotic event and one major bleed were observed. |
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| Keywords: | children coagulopathy COVID-19 thromboprophylaxis thrombosis |
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