The effects of Gymnema Sylvestre supplementation on lipid profile,glycemic control,blood pressure,and anthropometric indices in adults: A systematic review and meta-analysis |
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| Authors: | Mohammad Zamani Damoon Ashtary-Larky Saeed Nosratabadi Reza Bagheri Alexei Wong Mohammad Mahdi Rafiei Mojtaba Mahdavi Asiabar Pardis Khalili Omid Asbaghi Sayed Hosein Davoodi |
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| Institution: | 1. Department of Clinical Nutrition, School of Nutritional sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran;2. Nutrition and Metabolic Diseases Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran;3. Department of Nutrition, Electronic Health and Statistics Surveillance Research Center, Science and Research Branch, Islamic Azad University, Tehran, Iran;4. Department of Exercise Physiology, University of Isfahan, Isfahan, Iran;5. Department of Health and Human Performance, Marymount University, Arlington, USA;6. Centre de Recherche du Centre Hospitalier de l’Universit ́e de Montr ́eal (CRCHUM), Montréal, Canada
School of Kinesiology and Physical Activity Sciences, Université de Montréal, Montréal, Canada;7. Department of Physical Education and Sport Science, Sanandaj Branch, Islamice Azad University, Sanandaj, Iran;8. Department of Nutrition, Science and Research Branch, Islamic Azad University, Tehran, Iran;9. Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran |
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| Abstract: | There is a growing interest in the considerable health benefits of Gymnema Sylvestre (GS) supplementation, as some studies have reported that it may improve cardiometabolic risk factors. However, the widespread impact of GS supplementation on the parameters mentioned above is not fully resolved. Consequently, this study aimed to examine the effects of GS supplementation on lipid profile, glycemic control, blood pressure, and anthropometric indices in adults. Eligible randomized controlled trials (RCT), published up to November 2021, were identified through PubMed, Scopus, and ISI Web of Science databases. Six studies were included and analyzed using a random-effects model to calculate weighted mean differences (WMDs) with 95% confidence intervals (CI). All studies were conducted in adults that used a GC supplement (>1 week) and assessed our selected cardiovascular risk factors. Outcomes revealed that GS supplementation significantly decreased triglyceride (p < .001), total cholesterol (p < .001), low-density lipoprotein (p < .001), fasting blood sugar (p < .001), and diastolic blood pressure (p = .003). Some limitations, including notable heterogeneity, low quality of studies, and lack of diversity among research participants, should be considered when interpreting our results. Our outcomes suggest that GS supplementation may improve cardiovascular risk factors. Future large-high-quality RCTs with longer duration and various populations are needed to firmly establish the clinical efficacy of the plant. |
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| Keywords: | blood pressure cardiovascular risk factors glycemic control Gymnema Sylvestre lipid profile meta-analysis |
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