| 阿维A与甲氨喋呤治疗银屑病的疗效对比分析 |
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| 引用本文： | 何玉清,张锡宝,李常兴,刘玉梅,黄振明,陈绍谦. 阿维A与甲氨喋呤治疗银屑病的疗效对比分析[J]. 中国皮肤性病学杂志, 2005, 19(6): 346-348 |
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| 作者姓名： | 何玉清 张锡宝 李常兴 刘玉梅 黄振明 陈绍谦 |
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| 作者单位： | 广州市皮肤性病防治所,广东,广州,510095 |
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| 基金项目： | 广东省重点科技公关项目(99050) |
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| 摘 要： | 目的探讨第三代维甲酸类药阿维A与传统药物甲氨喋呤对银屑病疗效的影响。方法患者分别给予阿维A和甲氨喋呤治疗。用酶联免疫吸附试验(ELISA)检测银屑病患者外周血中IFNγ;用PASI评价患者病情严重程度;用生活质量测评表评价患者对药物的反应。结果①阿维A组患者外周血IFNγ水平下降大于甲氨喋呤组,组间差异有显著性(P<0.05);IFNγ含量与PASI的下降成正相关。②阿维A组副作用明显大于甲氨喋呤组。结论阿维A起效快,但皮肤干燥、瘙痒等副作用大;甲氨喋呤起效慢,但副作用小,患者容易接受。总体有效率阿维A组优于甲氨喋呤组,组间差异有显著性(P<0.05)。
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| 关 键 词： | 银屑病 阿维A 甲氨喋呤 |
| 文章编号： | 1001-7089(2005)06-0346-02 |
Comparison of the Effect of Acitretin and MTX on Treating Psoriasis |
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| HE Yu-qing,ZHANG Xi-bao,LI Chang-xing,et al. Comparison of the Effect of Acitretin and MTX on Treating Psoriasis[J]. The Chinese Journal of Dermatovenereology, 2005, 19(6): 346-348 |
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| Authors: | HE Yu-qing ZHANG Xi-bao LI Chang-xing et al |
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| Abstract: | Objective To discuss the effect of Acitretin and MTX on psoriasis treatment.Methods Using ELISA to detect the levels of IFN-γin culture supernatant fluids of psoriatic patients.Using PASI to assess the severity degree of patient's condition;Using quality of life list to evaluate the patient's response to drug.Results ①IFN-γlevels in psoriatic patients in Acitretin group decreased faster than in MTX group,and there was statistical difference between two groups(P<0.05);Meanwhile IFN-γ levels had a positive correlation to psoriatic patients’ PASI. ②Acitretin group had more side effects than MTX.Conclusion Compared with MTX,effect of the Acitretin was faster than MTX,but had more side effects than that of MTX;To total efficiency,Acitretin group was superior to MTX group,there was statistical difference between two groups(P<0.05). |
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| Keywords: | Psoriasis Acitretin MTX |
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