Complex translocation involving Ph chromosome in a patient with typical chronic myelogenous leukemia. |
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| Authors: | G Calabrese G Palka C A Westbrook D Sheer |
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| Institution: | Institute of Biology and Genetics, University of Chieti, Italy. |
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| Abstract: | We report a cytogenetic study of a patient with chronic myelogenous leukemia (CML) who, while displaying a Philadelphia (Ph) chromosome, resulting from a standard t(9;22) at diagnosis, during the chronic phase (CP) showed disappearance of the Ph and occurrence of new chromosome changes, including a marker probably arising from a translocation involving chromosome 17 and the Ph. In situ hybridization confirmed the cytogenetic appearance and demonstrated that the breakpoint on the Ph marker occurred below the BCR-ABL fusion gene. |
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