CD44v6、MMP-9在胃癌侵袭与转移中的作用

目的探讨CD44v6和MMP-9在胃癌中的表达及二者在胃癌侵袭与转移中的作用。方法采用免疫组化S-P法检测128例胃癌手术标本中CD44v6和MMP-9的表达。结果128例胃癌组织中CD44v6和MMP-9阳性表达率分别为58.59%(75/128)、64.06%(82/128),二者均与胃癌生长方式、浸润深度、淋巴结是否转移、TNM分期有关(P<0.05或0.01);弥漫型胃癌MMP-9阳性表达率明显高于肠型胃癌(P<0.01);MMP-9表达阳性的胃癌患者5年生存率较表达阴性者低(P<0.05);二者在胃癌中表达呈正相关,其共同表达者组发生淋巴结转移的比例明显高于二者仅其中之一阳性表达组或同为阴性表达组(P<0.05或0.01);其共同表达者组发生浆膜浸润的比例均明显高于同为阴性表达组(P<0.01)。结论CD44v6和MMP-9对胃癌的生长、浸润和转移有促进作用,CD44v6和MMP-9表达可作为判断胃癌生物学行为和预后的重要指标。

Role of CD44v6 and MMP- 9 in invasiveness and metastasis Potential of stomach cancer

Objective To outline the significances of CD44v6 and MMP-9 expressed in stomach cancer and the effect of them on metastasis and invasiveness of stomach cancer.Methods An immunohistochemical S-P method was used to detect the expression of CD44v6 and MMP-9 in 128 samples of stomach cancer after operation. Results In 128 cases of stomach tissues,of 75 cases(58.59%) expressed CD44v6 positively and of 82 cases(64.06%) expressed MMP-9 positively,both of them correlated to the stomach growth ways,invasive depth,with or without lymph node metastasis,TNM staging(P<0.05 or 0.01);the expression of MMP-9 in diffuse type stomach cancer were higher than that in intestinal-type stomach cancer(P<0.01).The five-year survival rate in patients with stomach cancer with expression of MMP-9 was lower than those without expression of MMP-9(P<0.05).Both of CD44v6 and MMP-9 in patients with stomach cancer had positive correlation to the cancer progression,the incidence of lymph node metastasis was higher in patients with both higher expression of CD44v6 and MMP-9 than those with only one of the positive expression or without both of the expression(P<0.05 or 0.01);of the cases that expressed both CD44v6 and MMP-9 were found with more serosal invasiveness than those without both of the expression(P<0.01).Conclusion CD44v6 and MMP-9 can promote the stomach cancer growth,invasiveness and metastasis of the stomach cancer,they can be used as an important marker for predicting the stomach cancer biological behavior and prognosis.