| 左旋四氢巴马汀对几种激动剂所致气管收缩作用的影响 |
| |
| 引用本文： | 吴绍光,李晓兰.左旋四氢巴马汀对几种激动剂所致气管收缩作用的影响[J].中国药理学通报,1990,6(3):179-182. |
| |
| 作者姓名： | 吴绍光 李晓兰 |
| |
| 作者单位： | 同济医科大学郧阳医学院药理教研室，同济医科大学郧阳医学院药理教研室，同济医科大学郧阳医学院药理教研室 十堰 442000，十堰 442000，十堰 442000 |
| |
| 摘 要： | 在离体豚鼠气管螺旋条L—THP抗BaCl_2,KCl,5-HT,His,Ach所致收缩作用与Ver及Pap均不同。L-THP抗BaCl_2,KCl,5-HT,His次最大反应量所致收缩的IC_(50)值分别为3.5×10~(-5)mol/L,4.5×10~(-5)mol/L,2.5×10~(-5)mol/L,8.9×10~(-5)mol/L。各激动剂对L—THP的敏感性与其对胞外钙的相对依赖性顺序相一致。但L-THP抗KCl及5-HT的作用强度无显著差异,提示L-THP能阻断钙内流并具相似强度的抗5-HT作用。
|
| 关 键 词： | 左旋四氢巴马汀 维拉帕米 罂粟碱 5-羟色胺 氯化钾 豚鼠气管 |
EFFECT OF L-THP ON CONTRACTION OF ISOLATION GUINEA PIG TRACHEA INDUCED BY SEVERAL AGONISTS |
| |
| Wu Shaoguang,Li Xiaolan,Zhao Guoju.EFFECT OF L-THP ON CONTRACTION OF ISOLATION GUINEA PIG TRACHEA INDUCED BY SEVERAL AGONISTS[J].Chinese Pharmacological Bulletin,1990,6(3):179-182. |
| |
| Authors: | Wu Shaoguang Li Xiaolan Zhao Guoju |
| |
| Abstract: | The antagonistic effects of L-THP, Ver and Pap to contraction of isolated guinea pig trachea preparations induced by BaCl2 10-3mol/L ,KC1 3×10-2mol/L, 5-HT 2×10-5mol/L, Ach 2×10-5mol/L and His 2× 10-5mol/L were studied.
The antagonistic effects of L-THP were different from Ver and Pap. The IC50 value of L-THP for contraction induced by BaCl2, KC1, 5-HT and His was 3 .5× 10-5mol/L , 4.5 × 10-5mol/L , 2.5×10-3 mol/L and 8.9× 10-5mol/L respectively. It was showed that sensibility of several agonists to inhibition by L-THP was correlated with dependence of extracellular Ca2+. The potencies of L-THP on anti-KCl and anti-5-HT actions were similar. The results suggested that LTHP possesses anti-calcium and anti-5-HT action on guinea pig trachea. |
| |
| Keywords: | L-tetrahydropalmatine Verapamil Papaverine KCl 5-hydroxytryptamine Guinea pig tracheal |
| 本文献已被 CNKI 维普 等数据库收录！ |
|
