口服加巴喷丁治疗原发性三叉神经痛的临床观察

目的探讨口服加巴喷丁治疗原发性三叉神经痛的疗效及不良反应。方法将158例原发性三叉神经痛患者随机分为加巴喷丁组和卡马西平组。加巴喷丁组78例,口服加巴喷丁后,将剂量调整到缓解疼痛为止,维持量一般为900～1200 mg。卡马西平组80例,口服卡马西平.调整剂量到缓解疼痛为止,维持量一般为600 mg。治疗后1个月,观察两组患者的疼痛缓解程度以及服药后的不良反应。结果加巴喷丁组和卡马西平组疼痛的总有效率分别为76.9%与77.2%。两组治疗效果的差异无统计学意义（P〉0.05）,但加巴喷丁组副作用发生率较低。结论加巴喷丁治疗原发性三又神经痛与卡马西平的效果相当,是治疗原发性三叉神经痛等神经病理性疼痛较好的药物。

Effect of gabapentin on primary trigeminal neuralgia

Objactive To investigate the curative effect and side effects of gabapentin to treat primary trigeminal neuralgia. Metheds One hundred and fifty eight patients with primary trigeminal neuralgia were randomly divided into two groups： gabapentin group （78 cases） and carbamazapine group （80 cases）. The dose was titrated to pain relief in gabapentin group and maintaned with the dose of 900-1200 mg. so as to the carbamazapine group. After one month, the effect of pain relief and side effect were observed . Results The total effective rates were 76.9 % and 77.2% respectively in gabapentin and carbamazepine groups, which were no statistical difference （P〉0.05）. But the side effects in gabapentin group was lower. Conclusion Gabapentin is an effective medicine to treat the primary trigeminal neuralgia, and its efficacy is similar to carbamazepine.