| 白细胞介素-2逆转急性白血病细胞多药耐药的临床研究 |
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| 引用本文： | 贾庆瑞,葛祥花,隋金财.白细胞介素-2逆转急性白血病细胞多药耐药的临床研究[J].白血病．淋巴瘤,2003,12(1):28-30. |
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| 作者姓名： | 贾庆瑞 葛祥花 隋金财 |
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| 作者单位： | 山东省临沂市人民医院,山东,临沂,276003 |
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| 摘 要： | 目的：研究白细胞介素-2（IL-2）对急性白血病细胞多药耐药的逆转作用。方法：选择27例复发和难治性急性白血病，用IL-2联合化疗药物治疗，通过白血病细胞P-糖蛋白（p170)。肺耐药蛋白（LRP）含量的变化和临床缓解率进行分析。结果：IL-2联合化疗药物治疗的急性白血病患者较单用联合化疗药物患者，白血病细胞p170,LRP表达减低。临床缓解率增加。结论：IL-2对急性白血病细胞的多药耐药有逆转作用；IL-2通过下调白血病细胞P170和LRP的表达，实现对急性白血病细胞多药耐药的逆转作用。
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| 关 键 词： | 白血病 急性 白细胞介素－2 多药耐药 P－糖蛋白 肺耐药蛋白 |
| 文章编号： | 1009-9921(2003)01-0028-03 |
| 修稿时间： | 2002年4月27日 |
CLINICAL STUDY OF REVERSAL EFFECT OF MULTIDRUG RESISTANCE IN ACUTE LEUKEMIA CELLS BY INTERLEUKIN-2 |
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| JIA Qing rui,GE Xiang hua,SUI Jin cai.Linyi People''''s Hospital.CLINICAL STUDY OF REVERSAL EFFECT OF MULTIDRUG RESISTANCE IN ACUTE LEUKEMIA CELLS BY INTERLEUKIN-2[J].Journal of Leukemia & Lymphoma,2003,12(1):28-30. |
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| Authors: | JIA Qing rui GE Xiang hua SUI Jin caiLinyi People's Hospital |
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| Abstract: | Objective:To investigate reversal effect of multidurg resistance in acute leukemia cells by interleukin 2(IL 2).Methods:27 patients with refractory and relapsed acute leukemia were elected.P glucoprotein (p170),lung resistance related protein (LRP) and clinical remission ratio was analysed after treatment of the patients.Results:The patients with acute leukemia treated by IL 2 and chmotherapy had lower expression of P 170 and LRP and high remission ratio than patients treated with only chmotherapy.There was statistical significant comparison ( P <0.05).Conclusion:Interleukin 2 has reversal effect of multidrug resistance in acute leukemia cells.It acted by lower express of P 170 and LRP. |
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| Keywords: | Leukemia Acute P glucoprotein Lung resistance related protein Multidrug resistance Interleukin 2 |
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