| β-蜕皮甾酮的分离及结构修饰 |
| |
| 引用本文： | 闫竟宇,程卯生,何艳,李铣.β-蜕皮甾酮的分离及结构修饰[J].沈阳药科大学学报,2006,23(11):702-705. |
| |
| 作者姓名： | 闫竟宇 程卯生 何艳 李铣 |
| |
| 作者单位： | 1. 沈阳药科大学,中药学院,辽宁,沈阳,110016
2. 沈阳药科大学,制药工程学院,辽宁,沈阳,110016 |
| |
| 摘 要： | 目的从露水草总甾酮中分离β蜕皮甾酮并对其进行结构修饰。方法采用硅胶柱色谱分离β蜕皮甾酮,并以其为原料通过化学合成的各种手段合成结构类似物,利用光谱分析方法对所得化合物进行结构确证。结果与结论从露水草总甾酮中分离了β蜕皮甾酮(20 hydroxyecdysone)及另一含量较大的筋骨草甾酮C(ajugasterone C)。以分离的β蜕皮甾酮为原料化学合成了5种植物甾酮。分别是2,3,20,22双异丙叉基β蜕皮甾酮(20 hydroxyecdysone 2,3,20,22 diacetonideⅠ)、20,22异丙叉基β蜕皮甾酮(20 hydroxyecdysone 20,22 acetonideⅡ)、2,3,20,22双异丙叉基25乙酰基β蜕皮甾酮(viticosterone E 2,3,20,22 diacetonideⅢ)、2,3异丙叉基β蜕皮甾酮(20 hy-droxyecdysone 2,3 acetonideⅣ)、2,3异丙叉基22羰基β蜕皮甾酮(22 oxo 20 hydroxyecdysone2,3 acetonideⅤ)。
|
| 关 键 词： | β-蜕皮甾酮 分离 结构修饰 |
| 文章编号： | 1006-2858(2006)11-0702-04 |
| 收稿时间： | 2006-02-08 |
| 修稿时间： | 2006年2月8日 |
Isolation and structural modification of 20-hydroxyecdysone |
| |
| YAN Jing-yu,CHENG Mao-sheng,HE Yan,LI Xian.Isolation and structural modification of 20-hydroxyecdysone[J].Journal of Shenyang Pharmaceutical University,2006,23(11):702-705. |
| |
| Authors: | YAN Jing-yu CHENG Mao-sheng HE Yan LI Xian |
| |
| Institution: | 1. School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China; 2. School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016, China |
| |
| Abstract: | Objective To isolate 20-hydroxyecdysone from the total phytoecdysteroids in Cyanotis arachnoidea C.B.Clarke and try its structure modification.Methods 20-hydroxyecdysone was isolated by chromatography on silica gel column and some analogues were obtained from 20-hydroxyecdysone via chemical methods.The products were identified on the basis of physicochemical properties and spectral analysis.Results and conclusions Ajugasterone C and 20-hydroxyecdysone were isolated from total phytoecdysteroids and five phytoecdysteroids were synthesized as 20-hydroxyecdysone 2,3,20,22-diacetonide;20-hydroxyecdysone 20,22-acetonide;Viticosterone E 2,3,20,22-diacetonide;20-hydroxyecdysone 2,3-acetonide;22-oxo-20-hydroxyecdysone 2,3-acetonide respectively. |
| |
| Keywords: | 20-hydroxyecdysone isolation structural modification |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
