| 可降解聚乙醇酸纤维材料浸提液的遗传毒性研究 |
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| 引用本文： | 韩倩倩,黄薇,宋谊萍,王召旭,李彦红,王春仁,黄清泉.可降解聚乙醇酸纤维材料浸提液的遗传毒性研究[J].癌变．畸变．突变,2012,24(5):359-361,364. |
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| 作者姓名： | 韩倩倩 黄薇 宋谊萍 王召旭 李彦红 王春仁 黄清泉 |
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| 作者单位： | 1. 中国食品药品检定研究院医疗器械检定所生物材料与组织工程室,北京,100050
2. 首都医科大学附属北京口腔医院急诊科,北京,100050 |
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| 基金项目： | 国家科技支撑计划项目(2012BAI22B01) |
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| 摘 要： | 目的:观察可降解聚乙醇酸(polyglycolic acid,PGA)生物支架材料是否具有引起基因突变的潜能。方法:采用Ames试验和小鼠淋巴瘤试验评价PGA浸提液的遗传毒性。结果:在Ames试验中,与阴性对照组比较,可降解PGA的浸提液均未引起4个试验菌株出现显著的回变菌落数改变(P0.5)。在小鼠淋巴瘤试验中,可降解PGA各个剂量浸提液组的克隆形成率较阴性对照组均无明显差异(P0.5),且显著小于阳性对照的克隆形成率(P0.5)。结论:可降解PGA纤维材料浸提液对于Ames试验菌株,小鼠淋巴瘤细胞无基因诱变性。
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| 关 键 词： | 可降解PGA材料 Ames试验 小鼠淋巴瘤试验 |
Study of the genotoxicity of the bio-degradable polyglycolide fiber materials |
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| HAN Qian-qian
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HUANG Wei
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SONG Yi-ping
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WANG Zhao-xu
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LI Yan-hong
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WANG Chun-ren
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HUANG Qing-quan.Study of the genotoxicity of the bio-degradable polyglycolide fiber materials[J].Carcinogenesis,Teratogenesis and Mutagenesis,2012,24(5):359-361,364. |
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| Authors: | HAN Qian-qian HUANG Wei SONG Yi-ping WANG Zhao-xu LI Yan-hong WANG Chun-ren HUANG Qing-quan |
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| Institution: | 1 (1.National Institute for Food and Drug Control,Center of Medical Devices,Beijing 100050;2.Beijing Stomatological Hospital, Emergency Department,Beijing 100050,China) |
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| Abstract: | OBJECTIVE:To investigate the genetic toxicity of bio-degradable polyglycolic acid(PGA) fiber materials and to assess its safety.METHODS:The bacterial reverse mutation study(Ames test) and the mouse lymphoma assay(MLA) were used to test the potential genotoxicity.RESULTS:In Ames test,the bio-degradable PGA fiber material extract did not increase the revertant colonies(P > 0.5).From the mouse lymphoma assay,there was no significant difference of the clone forming rate between the PGA fiber extract group and the negative control group(P > 0.5),however there was a significant difference between the PGA group and positive control group(P < 0.05).CONCLUSION:The bio-degradable PGA fiber material was not mutagenic as tested by Ames and mouse lymphoma assay. |
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| Keywords: | bio-degradable PGA fiber material Ames test mouse lymphoma assay |
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