环指蛋白43基因与肿瘤

环指蛋白43(RNF43)基因与人类多种肿瘤的发生发展密切相关,与其相关的肿瘤发病机制主要是RNF43基因的异常表达和基因突变.其编码的蛋白在结直肠癌、肝癌中通过多种信号通路参与肿瘤细胞的增殖、凋亡、侵袭,影响肿瘤的发生发展,发挥癌基因的作用;而在卵巢黏液性肿瘤、胰腺导管内乳头状黏液瘤中被认为是抑癌基因.

Ring finger protein 43 gene and cancer

Ring finger protein 43 (RNF43) gene is closely associated with the development of various types of human tumors.The mainly mechanisms of RNF43 gene are mutation and aberrant expression.Activated RNF43 protein participates in the proliferation, apoptosis, metastasis through some signal pathways and influences the tumorigenesis and development in colorectal cancer, hepatocellular carcinoma, which plays a role of oncogene.However, it is considered as a tumor suppressor gene in mucinous ovarian tumors and intraductal papillary mucinous neoplasms of the pancreas.