某中医医院连续3年女性生殖系统感染解脲脲原体的耐药性

目的了解某中医医院女性生殖系统解脲脲原体（Uu）感染患者连续3年的耐药现状和变化趋势。方法对该中医医院2011年1月-2013年12月皮肤性病科和妇科门诊及住院女性患者送检的白带及宫颈分泌物标本分离的Uu的耐药性进行回顾性分析。结果共分离Uu 327株，其3年耐药率，除多西环素（5.23%～6.12%）和交沙霉素（0～1.96%）较低外，其余抗菌药物均稍有增高，但差异无统计学意义（P＞0.05）。Uu对氧氟沙星、克拉霉素、司帕沙星的耐药率（42.11%～61.40%）较高，对交沙霉素、多西环素、美满霉素的耐药率（0～13.07%）较低，多药耐药现象较严重。结论该中医医院女性生殖系统感染患者分离的Uu耐药性较高。掌握Uu耐药现状和变化趋势，对于疾病的治疗和控制多药耐药菌株的产生非常必要。

Antimicrobial resistance of Ureaplasma urealyticum from reproductive systems of female patients at a traditional Chinese medicine hospital in three consecutive years

Objective To investigate antimicrobial resistance and change trends ofUreaplasma urealyticum （Uu） from reproductive system of female patients at a traditional Chinese medicine hospital in three consecutive years. Methods Antimicrobial resistance of Uu isolated from gynaecology leucorrhea and cervical secretion specimens of patients of dermatology ＆ sexually transmitted diseases department and gynaecology department from January 2011 to December 2013 were analyzed retrospectively.Results A total of 327 Uu strains were isolated,except resistance rates of Uu to doxycycline（5.23%-6.12%）and josamycin（0-1 .96%）remained at a relatively low level in three consecutive years,resistance rate to the other antimicrobials showed an upward trend year by year,but the difference was not significant （P 〉0.05）.The resistance of Uu to ofloxacin,clarithromycin and sparfloxacin were relatively high（42.11 %-61 .40%）,to josamycin,doxycycline and minocycline were lower（0-13.07%）,and multidrug re-sistance was serious.Conclusion Antimicrobial resistanc of Uu isolated from reproductive system of female patients in this hospital is high.It is necessary to realize the status and change trends of antimicrobial resistance of Uu for the treatment of disease and control of the emergence of multidrug resistance pathogens.