液基薄层细胞检测系统与阴道镜下活检在诊断子宫颈病变中的价值

目的探讨液基薄层细胞检测系统(LCT)联合阴道镜及阴道镜下宫颈活检对宫颈上皮内瘤变(CIN)的诊断价值。方法回顾性分析7118例LCT筛查结果及其中778例细胞学阳性行阴道镜下活检的病理结果,167例虽细胞学阴性,但临床高度可疑,行阴道镜检出并取活检。结果7118例患者中,778例LCT检查提示不典型鳞状细胞以上病变者,再行阴道镜下活检发现CIN以上病变429例,检出率为6.03%(429/7118)。167例LCT检查阴性但临床高度可疑病例,行镜下活检CIN以上病变78例,总检出率为7.12%(429+78)/7118]。两者比较差异显著(P<0.01)。结论采用LCT筛查可早期发现宫颈病变,细胞学阳性或临床可疑者应配合阴道镜检查及镜下活检可提高CIN的检出率,但如果同时进行阴道镜检查可提高CIN的检出率。

Value of Liquid-Based Thin-Layer Cell Detection System and Cervical Biopsy Vaginoscopy in Diagnosis of Cervical Lesion

Objective To study the diagnostic value of liquid-based thin-layer cell detction system(LCT)and cervical biopsy vagionscopy for cervical intraepithelial neoplasia(CIN).Method The clinical information of 7118 patients that received LCT and 778 cases of positive cytological result that received cervical biopsy were retrospectively analyzed.167 patients with negative result in cytological test received cervical biopsies vaginoscopy because of their high-grade clinical suspicion.Results In 7118 patients,429 cases was diagnosed as CIN by cervical biopsy,the diagnosis rate was 6.03%(429/7118).In 167 patients,78 cases of 778 cases that were suggested as untypical squamous cell lesions by LCT were diagnosed as CIN by cervical biopsy.The total diagnosis rate is 7.12%(429+78)/7118].There was a significant difference between them(P<0.01).Conclusions LCT could detect cervical lesion in its early stage.The patients whose cytological test results are positive or clinical high-grade suspicious should receive cervical biopsy vaginoscopy,which may benefit to the increase of detection rate of CIN.