氟芬那酸丁酯软膏联合维A酸乳膏治疗慢性湿疹和神经性皮炎疗效观察

目的观察氟芬那酸丁酯软膏联合维A酸乳膏治疗慢性湿疹和神经性皮炎的疗效。方法将入选的174例慢性湿疹和神经性皮炎患者随机分为两组,治疗组每天早晨和中午各1次局部外搽氟芬那酸丁酯软膏,晚上局部外搽0.1%维A酸乳膏1次;对照组局部搽0.05%卤米松乳膏,早、晚各1次,4周后观察疗效,并随访6个月。结果治疗组有效率78.88%,对照组为80.95%,两组有效率比较,差异无显著性意义(P>0.05);治疗组复发率13.89%,对照组为40.63%,两组复发率比较,差异有显著性意义(P<0.05)。结论氟芬那酸丁酯软膏联合维A酸乳膏治疗慢性湿疹和神经性皮炎疗效显著,复发率低。

Observation on the Effect of Butyl Flufenamate Ointment Combined with Tretinoin Ointmen Treating Chronic Eczema and Dermatoneuritis

Objective To observe the effect of Butyl flufenamate ointment combined with tretinoin ointmen on treating chronic eczema and dermatoneuritis.Method 174 patients were divided randomly into two groups,butyl flufenamate ointment was topicaily used for the therapy group two times daily in the morning and at noon,0.1% tretinoin ointment once a time in the evening;0.05% halometasone cream was topicaily used for the control group once a time both in the morning and evening.The effect was observed after four weeks and the patients were followed up for six months.Results Efficient rate of therapy group was 78.88%,while the control group was 80.95%,which had no significantly difference(P> 0.05);relapse rate of therapy group was 13.89%,while control group was 40.63%,which had significant difference(P< 0.05).Conclusion Butyl flufenamate ointment combined with tretinoin ointmen is effect on chronic eczema and dermatoneuritis with lower relapse rate.