Transient middle cerebral artery occlusion induces microglial priming in the lumbar spinal cord: a novel model of neuroinflammation |
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| Authors: | Katie Moisse Ian Welch Tracy Hill Kathryn Volkening Michael J Strong |
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| Affiliation: | (1) Cell Biology Research Group, Robarts Research Institute, London, Ontario, Canada;(2) Department of Pathology, University of Western Ontario, London, Ontario, Canada;(3) Department of Animal Care and Veterinary Services, University of Western Ontario, London, Ontario, Canada;(4) Department of Clinical Neurological Sciences, the University of Western Ontario, London, Ontario, Canada |
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| Abstract: | Background Middle cerebral artery occlusion (MCAo) in mice results in a brain infarct, the volume of which depends on the length of occlusion. Following permanent occlusion, neuropathological changes – including a robust glial inflammatory response – also occur downstream of the infarct in the spinal cord. |
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