肝癌根治性切除术后联合肝动脉化疗栓塞和门静脉化疗对预防复 …

目的 探讨在肝癌根治性切除术后联合肝动脉化疗栓塞（ｈｅｐａｔｉｃ ｃｈｅｍｏｅｍｂｏ－ｌｉｚａｔｉｏｎ，ＨＡＣＥ）和门静脉化疗（ＰＶＣ）对预防术后复发的价值。方法 总结１９９１年８月～１９９５年７月收治符合根治性切除的原发性肝癌患者８１例。其中，术后联合ＨＡＣＥ和ＰＶＣ（Ⅰ组）２３例，单纯ＨＡＣＥ（Ⅱ组）３０例，未做特殊处理（Ⅲ组）２８例。全部患者随访３年以上。将３组进行对比研究。结果 患者术后１

Combined hepatic artery chemoembolization and portal vein chemotherapy after radical resection of hepatocellular carcinoma to prevent recurrence]

OBJECTIVE: To study the value of combined hepatic artery chemoembolization (HACE) and portal vein chemotherapy (PVC) after radical resection of hepatocellular carcinoma (HCC) to prevent recurrence. METHODS: From August 1991 to July 1995, 81 HCC patients were undergone radical tumor resection. After operation, combined treatment with HACE and PVC was given in group I (28 cases), HACE alone in group II (30 cases), nothing in group III (28 cases). All patients were followed up over 3 years. RESULTS: Recurrence rate at one year after surgery was significantly lower in group I and II than in group III; at two years, it was lower in group I than in group II and III. Survival rate at one year was notably higher in group I and II than in group III; at 2 years, it was higher in group I than in group II and III. Recurrence rate and survival rate were similar in group I and group II at 3 and 5 years after surgery. Tumor larger than 5 cm, no capsule, multiple foci, AFP > 400 micrograms/L were high risk factors of postoperative recurrence. CONCLUSION: After radical resection of HCC, combined use of HACE and PVC is superior to HACE alone to reduce recurrence rate and to increase survival rate within 2 years after operation. Such remarkable difference no more exists at 3 and 5 years following operation.