棉酚治疗子宫内膜异位症和子宫肌瘤的临床观察及其作用部位

在我国某些地区,人们食用生棉籽油后男性发生不育,女性出现闭经和子宫萎缩。大量动物实验证实其有效成份棉酚能抑制精子发生并已应用于临床作为男性避孕药。1977年起棉酚试用于女性治疗功能性子宫出血有一定疗效,并发现对子宫内膜有明显的萎缩作用。根据棉酚对子宫内膜的特异作用,我们重点观察了对子宫内膜异位症和子宫肌瘤的疗效并探讨其作用部位。

A Clinical observation of the Gossypol Treatment of Endometriosis and Uterine Myoma end Its Location of Action

The gossypol treatment of endometriosis and uterine myoma resulted in not only inhibition of ovulation,lowering of estrogen level and rise of blood FSH and LH.but also marked atrophy of endometrium causing pseudomenopause.The therapeutic effect was distinguished and sustained.It can serve as a new method in the conservative treatment of endometriosis and myoma.Observation after the withdrawal of gossypol has shown that most patients resumed menstruation within half year and remained well,i.e.,the myoma remained smaller and endometriosis nodules less than those before the treatment. Ovarian functions and basal body temperature recovered in most patients.Hence.the gossypol effect was reversible.Although the drug could induce pseudomenopause,there was no permanent damage in younger patients.In older patients,menopause was obtained smoothly.The therapeutic effect of gossypol was about the same as danazol.Gossypol tends to increase potassium excretion and have a certain degree of side effects,which might be minimized when smaller effective doses are attempted in future clinical trials.The article has also discussed the location of action of gossypol.