Effects of sennosides on colonic myoelectrical activity in man

The effects of sennosides on colonic myoelectrical activity were investigated in man. Spiking activity of the left and sigmoid colons was continuously recorded in seven constipated patients during two sessions from 5:00 PM to 9:00 am. Each patient received orally at 7:00pmon two consecutive days 30 mg of sennosides one day (sequence S) and placebo on the other (sequence P) in a random fashion. A significant (P<0.05) increase of peristaltic activity (migrating long spike bursts or MLSBs) after sennosides was observed between 1:00 and 7:00am,and a corresponding decrease between 7:00 and 9:00am.No change was noted in total short spike burst (SSB) activity or in SSBs characteristic of the rectosigmoid area. This study indicates that the main modification of colonic motility induced by sennosides was a stimulation of propulsive activity (MLSBs), which occurred between 6–12 hr after oral administration, the delay required for orocecal transit and metabolism of the drug.This work was supported in part by INSERM grants 1300-05, 30, 39; in part by Fondation pour la Recherche Médicale; and in part by Institut National de la Recherche Agronomique.