不同促透剂对脂溶性基质制剂脐中穴经皮给药作用研究

目的:研究三种促透皮吸收剂即脂溶性氮酮、水溶性氮酮、二甲基亚砜对脂溶性基质脐中穴经皮给药制剂吸收的促透作用。方法:制备含不同浓度的促透皮吸收剂的脂溶性基质的制剂,将昆明小鼠脐部皮肤剥离,进行预处理,采用Franz扩散池体外透皮试验,于不同时间取样,用高效液相色谱法测定接收池中制剂主要成分的含量。结果:加入促透皮吸收剂的最适宜水平组与空白组透过量有显著性差异,P0.05;脂溶性氮酮组、水溶性氮酮组1%～5%、二甲基亚砜用量在30%～35%均有较好的促透作用,其中脂溶性氮酮组2%为最优,经皮吸收量与时间呈正相关性;与氮酮浓度无相关性;脂溶性氮酮组高于相应水溶性氮酮组。结论:加入促透皮吸收剂的最适宜水平组与空白组透过量有显著性差异(P0.05);经皮吸收量与时间呈正相关性;脂溶性氮酮组高于相应水溶性氮酮组。

The Different Effect of Admit Accelerator in Researching on Giving Medicine Which is in the Grease Dissolves Nature base Material by Skin

Objective:Studies three kinds to press thoroughly the skin absorbent is the fat soluble nitrogen alkone,the water-soluble nitrogen alkone,the dimethylsulfoxide the hole the preparation absorption presses thoroughly the function to the fat soluble matrix navel in giving medicine by skin.Methods:The preparation pressed thoroughly the skin absorbent including the different density the fat soluble matrix preparation,the Kunming mouse navel region skin peeling,would carry on the pretreatment,used outside the Fra...