| 聚乙二醇影响葡萄糖吸湿性的初步研究 |
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| 引用本文： | 王振华,田军,孔秋玲,詹晓毅,潘艳,曾令清,曲园园. 聚乙二醇影响葡萄糖吸湿性的初步研究[J]. 中药新药与临床药理, 2010, 21(2) |
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| 作者姓名： | 王振华 田军 孔秋玲 詹晓毅 潘艳 曾令清 曲园园 |
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| 作者单位： | 广州中医药大学,广州,510006 |
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| 摘 要： | 目的探讨药物抗吸湿新方法。方法葡萄糖为模型物,加入不同比例的聚乙二醇,制成溶液,冷冻干燥,粉碎,测定临界相对湿度。结果葡萄糖的临界相对湿度为77.64%,含有3%、5%、10%、15%、20%、33%聚乙二醇的葡萄糖混合物的临界相对湿度分别为92.79%、88.33%、89.51%、87.67%、83.77%、81.36%。结论聚乙二醇可显著降低葡萄糖的吸湿性。推断可通过加入聚乙二醇降低与葡萄糖有相同吸湿机制药物的吸湿性。
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| 关 键 词： | 聚乙二醇 抗吸湿 葡萄糖 临界相对湿度 |
Preliminary Study of Polyethylene Glycol on Counteracting Moisture Absorption of Glucose |
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| WANG Zhenhua,TIAN Jun,KONG Qiuling,ZHAN Xiaoyi,PAN Yan,ZENG Lingqing,QU Yuanyuan. Preliminary Study of Polyethylene Glycol on Counteracting Moisture Absorption of Glucose[J]. Traditional Chinese Drug Research & Clinical Pharmacology, 2010, 21(2) |
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| Authors: | WANG Zhenhua TIAN Jun KONG Qiuling ZHAN Xiaoyi PAN Yan ZENG Lingqing QU Yuanyuan |
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| Affiliation: | WANG Zhenhua,TIAN Jun,KONG Qiuling,ZHAN Xiaoyi,PAN Yan,ZENG Lingqing,QU Yuanyuan(Guangzhou University of Chinese Medicine,Guangzhou 510006,China) |
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| Abstract: | Objective To study a new method for increasing moisture absorption resistance of the medicine.Methods The glucose(model)and polyethylene glyco(lantagonist)were mixed in certain ratio and then were frozen,dried,grinded for the measurement of the critical relative humidity(CRH).Results The CRH of glucose was 77.64 %.The CRH of glucose mixture with polyethylene glycol in the proportions of 3 %,5 %,10 %,15 %,20 %,and 33 % was 92.79 %,88.33 %,89.51%,87.67 %,83.77 %,and 81.36 %,respectively.Conclusion Polyethylen... |
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| Keywords: | Polyethylene glycol Moisture absorption resistance Glucose Critical relative humidity |
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