| 注射用刺五加对脑缺血的保护作用 |
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| 引用本文： | 封国峥,王春华,魏晶.注射用刺五加对脑缺血的保护作用[J].沈阳药科大学学报,2003,20(1):38-40. |
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| 作者姓名： | 封国峥 王春华 魏晶 |
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| 作者单位： | 1. 辽宁省药品检验所药理室,辽宁,沈阳,110023
2. 沈阳市第五人民医院药剂科,辽宁,沈阳,110023 |
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| 摘 要： | 目的研究注射用刺五加对小鼠全脑缺血及对大鼠不完全脑缺血的保护作用。方法小鼠尾静脉给予饱和氯化镁溶液 0 1mL ,形成全脑缺血模型 ,观察注射用刺五加对小鼠张口喘气维持时间的影响 ;结扎大鼠双侧颈总动脉及迷走神经形成急性实验性不完全脑缺血模型 ,观察药物对大鼠缺血后脑含水量、脑指数及乳酸脱氢酶增加的抑制影响。结果注射用刺五加 ( 1 4 8mg/kg)能显著延长小鼠张口喘气时间 ,对小鼠全脑缺血有保护作用 ;注射用刺五加 ( 80mg/kg)能显著抑制大鼠脑含水量、脑指数及乳酸脱氢酶的增加。结论注射用刺五加具有抗脑缺血作用
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| 关 键 词： | 刺五加 注射剂 全脑缺血 不完全脑缺血 脑缺血 |
| 文章编号： | 1006-2858(2003)01-0038-03 |
| 修稿时间： | 2002年9月15日 |
Protective effects of Acanthopanax senticosus(Rupr.et Maxim.)Harms used for the injection on the brain ischemia in mice and rats |
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| FENG Guo-zheng ,WANG Chun-hua ,WEI Jing.Protective effects of Acanthopanax senticosus(Rupr.et Maxim.)Harms used for the injection on the brain ischemia in mice and rats[J].Journal of Shenyang Pharmaceutical University,2003,20(1):38-40. |
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| Authors: | FENG Guo-zheng WANG Chun-hua WEI Jing |
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| Institution: | FENG Guo-zheng 1,WANG Chun-hua 2,WEI Jing 1 |
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| Abstract: | Objective To investigate the protective effects of the Acanthopanax senticosus used for the injection on the deep cerbral ischemia in mice and shallow cerbral ischemia in rats.Methods The mode of the deep cerebral ischemia by the intravenous injection of the saturated MgCl 2 (0.1 mL) and the effects of the drug on the survival time in mice were studied; the prohibitive effects of the drug were studied about the increase on the brain water or the brain index and LDH-L in rats.Results Acanthopanax senticosus( 148 mg/kg) markedly prolongs the survival time of the mice, and has protective effects on the deep cerebral ischemia.The Acanthopanax senticosus ( 80 mg/kg) signifcantly decreases the increase of the brain water or the brain index and LDH-L in rats.Conclusion The Acanthopanax senticosus used for the injection has protective effects on the cerebral ischemia. |
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| Keywords: | Acanthopanax senticosus injection deep cerebral ischemia shallow cerebral cerebral ischemia |
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