术前sCD40L预测冠脉支架后再狭窄的临床价值研究

目的探讨冠心病患者支架植入术前sCD40L对再狭窄的诊断预测价值。方法选择成功接受普通支架置入术的稳定型心绞痛和不稳定型心绞痛患者共92例,分别于支架术前,术后第1、5、15天和180天取外周静脉血测定血清sCD40L。所有患者随访6个月。结果支架内再狭窄率23.9%(22/92)。再狭窄患者支架术前和术后血清sCD40L浓度均显著高于无再狭窄患者术前sCD40L浓度;再狭窄患者支架术后高水平sCD40L持续至术后6个月,而无再狭窄患者术后5天恢复至正常。根据受试者工作特征曲线确定术前血清sCD40L>3.96μg/L为截断值,计算术前sCD40L诊断再狭窄的敏感性、特异性、阳性预测值(PPV)、阴性预测值(NPV)、准确度和阳性似然比分别为72.7%、90%、69.6%、91.3%、85.9%和7.27。多变量Logistic回归分析发现,在校正混杂因素后,术前sCD40L是术后再狭窄独立预测因子,OR1.92(95%CI1.39～2.64,P=0.013)。结论再狭窄患者支架术前、术后血清sCD40L水平增加提示可能与支架内再狭窄有关。支架术前血清sCD40L是术后再狭窄的独立预测因子,术前sCD40L有...

Clinical value of preprocedural soluble CD40L ligand for predicting restenosis after coronary stent implantation in patients with coronary heart disease

Objective To investigate the predictive value of preprocedural soluble CD40L ligand for in-stent restenosis after coronary stent implantation in patients with coronary heart disease.MethodsWe enrolled 92 patients with stable angina and unstable angina who underwent successful stent implantation,Serum sCD40L was measured before and 1,5,15,and 180 days after stent implantation.The patient follow-up was 6 months.Resultsangiographically proven in-stent restenosis occurred in 22 patients(23.9%).patients had prep...