早产低体重呼吸暂停患儿应用不同剂量枸橼酸咖啡因及与氨茶碱治疗疗效比较

为比较枸橼酸咖啡因与氨茶碱治疗早产低体重呼吸暂停患儿的疗效,120例早产低体重呼吸暂停患儿,依据治疗方法不同分为高剂量或低剂量枸橼酸咖啡因、氨茶碱,每组各40例,观察治疗后三组临床效果、血气指标、不良反应及患儿临床结局。结果显示,高剂量组拔管成功率最高,呼吸暂停总次数、机械通气天数、氧疗天数均最短,低剂量组次之,氨茶碱组最低/最长； 三组血氧分压(PaO₂)、血氧pH值(pH)在治疗后明显升高,动脉血二氧化碳分压(PaC₂)明显降低,且不良反应在各组之间也存在差异。高剂量枸橼酸咖啡因治疗早产低体重呼吸暂停患儿临床积极作用较低剂量及氨茶碱有明显优势,可作为治疗早产低体重呼吸暂停患儿首选药物方案。

Comparison of the effects of different doses of caffeine citrate and aminophylline in the treating premature infants with low birth weight and apnea

To compare the effects of different doses of caffeine citrate and aminophylline in the treating premature infants with low birth weight and apnea.120 premature infants with low birth weight and apnea in our hospital were selected as study subjects according to different treatment methods,and they were divided into high-dose caffeine citrate,low-dose caffeine citrate and aminophylline groups (n=40).The clinical effect,blood gas indexes,adverse reactions and clinical outcomes were observed.Results show that the success rate of extubation in high -dose caffeine citrate group was the highest,the total times of apnea,duration of mechanical ventilation and oxygen therapy were the least and the shortest,followed by low dose group and aminophylline group.After treatment,Pa_2and pH were significantly higher than those before treatment while PaC₂ was significantly lower,and the changes in high dose group were the most significant,followed by low dose group and aminophylline group.The side effects among the three groups had significant difference.High-dose caffeine citrate has more advantages over low-dose caffeine citrate and aminophylline in the treatment of premature infants with low birth weight and apnea.It can be used as a preferred treatment plan for premature infants with low birth weight and apnea.