| Epstein-Bar病毒潜伏膜蛋白在喉癌组织中的表达 |
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| 引用本文： | 刘振声,邓永江,李家喜,丁华野,郭志祥,曾毅. Epstein-Bar病毒潜伏膜蛋白在喉癌组织中的表达[J]. 中华实验和临床病毒学杂志, 1997, 0(2) |
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| 作者姓名： | 刘振声 邓永江 李家喜 丁华野 郭志祥 曾毅 |
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| 作者单位： | 中国预防医学科学院病毒学研究所，解放军北京军区总医院病理科，沈阳空军医院耳鼻喉科，空军总医院耳鼻喉科 |
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| 摘 要： | 为了探讨Ｅｐｓｔｅｉｎ－Ｂａｒ病毒在喉鳞癌细胞中的表达情况，对９０例喉鳞癌组织进行了Ｅｐ－ｓｔｅｉｎ－Ｂａｒｒ病毒潜伏膜蛋白（ＥＢＶ－ＬＭＰ－１）的检测，结果显示，ＬＭＰ－１主要定位于细胞膜和细胞浆内，９０例喉鳞癌中ＬＭＰ－１阳性者４１例，阳性检出率为４５．５％，其中低分化鳞癌阳性率为４４％（１２／２７），中分化鳞癌为５２％（２５／４８），高分化鳞癌为２６．６％（４／１５）。提示，ＥＢ病毒不仅存在于低分化喉鳞癌中，也存在于高分化鳞癌中，喉癌的发生可能与ＥＢ病毒感染有关。
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| 关 键 词： | 喉肿瘤 鳞状细胞 Epstein-Barr病毒 疱疹病毒科 |
Expression of Epstein-Barr virus latent membrane protein (EBV-LMP) in human laryngeal carcinoma |
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| Liu Zhensheng,Deng Yongjiang,Zeng Yi,et al.. Expression of Epstein-Barr virus latent membrane protein (EBV-LMP) in human laryngeal carcinoma[J]. Chinese journal of experimental and clinical virology, 1997, 0(2) |
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| Authors: | Liu Zhensheng Deng Yongjiang Zeng Yi et al. |
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| Affiliation: | Liu Zhensheng,Deng Yongjiang,Zeng Yi,et al. Institute of Virology,Chinese Academy of Preventive Medicine,Beijing 100052 |
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| Abstract: | In order to investigate the expression of Epstein-Barr virus in human laryngeal carcinoma, immunohistochemical study for Epstein-Barr vitus latent membrane protein (EBV LMP) was performed on 90 laryngeal specimens taken from laryngeal carcinoma patients. The results showed that LMP was localized on the cell membrance and in cytoplasm. LMP was detected in 41 of 90(45 5%) laryngeal squamous cell carcinoma, among them the positive rates of poorly differentiated, middle differentiated and well differentiated squamous carcinoma were 44%(12/27), 52%(25/47) and 26 6%(4/15) respectively. This study indicated that EB virus was not only presented in poorly differentiated carcinoma, it was also presented in well differentiated carcinoma. The development of laryngeal squamous carcinoma is related to the infection of EB virus. |
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| Keywords: | Laryngeal neoplasms Squamous cell Epstein Barr virus Herpesviridae |
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