| 福建HTLV-I的亚型分析 |
| |
| 引用本文： | 王惠榕,萧剑雄,严延生,吴珍红.福建HTLV-I的亚型分析[J].海峡预防医学杂志,2004(4). |
| |
| 作者姓名： | 王惠榕 萧剑雄 严延生 吴珍红 |
| |
| 作者单位： | 福建省疾病预防控制中心 福州350001
(王惠榕，萧剑雄，严延生)，福建省疾病预防控制中心 福州350001(吴珍红) |
| |
| 基金项目： | 福建省卫生厅青年科技基金资助 (项目号 :2 0 0 2 1 18) |
| |
| 摘 要： | 目的 ]分析福建省HTLV Ⅰ毒株的亚型 ,进一步明确基因型。 方法 ]用PCR的方法扩增福建 5株样品的Env及LTR区基因 ,测序后与来自世界各地的代表株进行比较、分析 ,构建进化树。结果 ] 5株样品与WHP、MT2比较 ,在已鉴定的B细胞表位区 ,不同的分离株相当保守 ,没有变异。结论 ]来自福建的分离株与日本、台湾及汕头的代表株最接近 ,属于HTLV ⅠA亚型 (Cosmopolitan)的Transcontinental亚群。
|
| 关 键 词： | 人类嗜T细胞病毒Ⅰ(HTLV-Ⅰ) 序列测定 聚合酶链反应(PCR) |
Analysis on Subtype of Human T-cell Lymphotropic Virus Type I in Fujian |
| |
| WANG Hui-Rong,XIAO Jian-Xiog,YAN Yan-Sheng.Analysis on Subtype of Human T-cell Lymphotropic Virus Type I in Fujian[J].Strait Journal of Preventive Medicine,2004(4). |
| |
| Authors: | WANG Hui-Rong XIAO Jian-Xiog YAN Yan-Sheng |
| |
| Abstract: | Objective To study the subtype of Human T-cell Lymphotropic Virus Type I (HTLV-I) in Fujian. The gene of proviral envelope region and long terminal repeat region from 5 HTLV-I strains were amplified by PCR. They were sequenced and compared with other isolates from different areas of the world and constructed the phylogenetic tree. The comparison of 5 HTLV-I strains with WHP and MT2 from Shantou and Japan showed they were conservative at B cell epitope regions and no deletion and insertion. Conclusion ] The strains from Fujian were most close to the isolates from Japan,Taiwan and Shantou. They belong to Transcontinental subgroup of HTLV-I subtype A (Cosmopolitan). |
| |
| Keywords: | |
| 本文献已被 CNKI 等数据库收录！ |
