从络病学说论治糖尿病肾病及相关研究

依据络病学说探讨糖尿病肾病中医病机,指出气阴两虚是糖尿病肾病的发病基础,络脉瘀阻、津凝痰聚是其主要病理环节,络息成积为主要病理改变。依据"益气养阴、祛瘀化痰、通络消积"法制定的通肾络胶囊组方,对糖尿病肾病大鼠肾脏功能有明显保护作用,对细胞外基质成分及调控机制有明显的影响。理论及实验研究初步阐明,络息成积的病理改变与糖尿病肾病肾脏细胞外基质成分及其调控机制具有内在相关性,佐证了络病学说的科学价值。

Treatment of Diabetic Nephropathy from Collateral Disease Theory and Its Related Experimental Research

Applying collateral disease theory to investigate the pathogenesis of diabetic nephropathy in traditional Chinese medicine, it is illuminated that deficiency of both qi and yin is the pathological basis of diabetic nephropathy(DN), collaterals blocked by phlegm-stasis is the major pathological factor, and masses developed from obstruction of collaterals is the main pathological change. So the therapeutic method for DN is established as supplementing qi and nourishing yin, removing blood stasis and resolving phlegm, expelling masses to dredge collaterals, with which "Tongshenluo Capsule" is formulated. The experiments indicate that "Tongshenluo Capsule" protect renal function, and has remarkable regulational effect on the components of extracellular matrix (ECM) in DN rats. And it is also illuminated that there is correlation between the pathological change of masses developed from obstruction of collaterals and the composition and control mechanism of ECM in the primary theoretical and experimental researches.