SPF-32629 A and B, novel human chymase inhibitors produced by Penicillium sp |
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| Authors: | Shimatani Takuro Hosotani Nobuo Ohnishi Masako Kumagai Kazuo Saji Ikutaro |
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| Institution: | Exploratory Research Group, Research Division, Sumitomo Pharmaceuticals Co., Ltd., 4-2-1 Takatsukasa, Takarazuka, Hyogo 665-0051, Japan. takuro-shimatani@ds-pharma.co.jp |
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| Abstract: | Two new human chymase inhibitors, SPF-32629A and B, were isolated from the cultured broth of Penicillium sp. SPF-32629. These structures were determined by spectroscopic methods and identified as new pyridone compounds. SPF-32629B was the carboxylated derivative of SPF-32629A. SPF-32629A and B specifically inhibited human chymase among four serine proteases tested with the IC50 of 0.25 and 0.42 microg/ml, respectively. |
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