| ZTC1+1天然澄清剂在清开灵口服液制备工艺中的应用 |
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| 引用本文： | 祝志贤,梁秋文,程婉玲.ZTC1+1天然澄清剂在清开灵口服液制备工艺中的应用[J].药学实践杂志,2009,27(4):274-275,304. |
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| 作者姓名： | 祝志贤 梁秋文 程婉玲 |
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| 作者单位： | 广州白云山明兴制药有限公司,广东,广州,510250 |
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| 摘 要： | 目的：考察ZTC1＋1天然澄清剂在清开灵口服液中的澄清效果。方法：以清开灵口服液中含氮量为指标，采用正交试验进行优选，找出理想的ZTC1＋1天然澄清剂处理工艺，并研究澄清剂在口服液中的残留量。结果：ZTC1＋1天然澄清剂既能保留清开灵口服液的有效成分，又能保证制剂的稳定；并与澄清剂的加入次序、反应温度两个因素有关。在清开灵口服液中无ZTC1＋1天然澄清剂残留。结论：ZTC1＋1天然澄清剂的澄清工艺可代替清开灵口服液的醇沉工艺。
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| 关 键 词： | 清开灵口服液 ZTC1+1天然澄清剂 |
| 收稿时间： | 2008/10/22 0:00:00 |
Application of ZTC1+1 natural clarifying agents in Qingkailing oral liquid |
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| ZHU Zhi-xian,LIANG Qiu-wen and CHENG Wan-ling.Application of ZTC1+1 natural clarifying agents in Qingkailing oral liquid[J].The Journal of Pharmaceutical Practice,2009,27(4):274-275,304. |
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| Authors: | ZHU Zhi-xian LIANG Qiu-wen and CHENG Wan-ling |
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| Institution: | Guangzhou Baiyunshan Mingxing Pharmaceuticals Company, Guangzhou 510250, China;Guangzhou Baiyunshan Mingxing Pharmaceuticals Company, Guangzhou 510250, China;Guangzhou Baiyunshan Mingxing Pharmaceuticals Company, Guangzhou 510250, China |
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| Abstract: | Objective: To study the effect of ZTC1+1 natural clarifying agents on the purification of Qingkailing oral liquid.Methods:The nitrogen content of Qingkailing oral liquid was taken as index.The optimum conditions were obtained by orthogonal experimentations.Results: The result showed that ZTC1+1 natural clarifying agents can effectively improve the content of Qingkailing oral liquid.The purifying effect was relative to the addition order of ZTC1+1 natural clarifying agents and the flocculation temperature.Conclusion:ZTC1+1 natural clarifying agents can be used for production of Qingkailing oral liquid. |
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| Keywords: | Qingkailing oral liquid ZTC1+1 natural clarifying agents |
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