| 注射用洋参生脉粉针对急性心肌缺血的保护作用 |
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| 引用本文： | 李欢,周晓棉,张麟,王玉姝,曹颖林.注射用洋参生脉粉针对急性心肌缺血的保护作用[J].沈阳药科大学学报,2007,24(8):508-511. |
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| 作者姓名： | 李欢 周晓棉 张麟 王玉姝 曹颖林 |
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| 作者单位： | 1. 沈阳药科大学,药学院,辽宁,沈阳,110016
2. 黑龙江省中医医院,药剂科,黑龙江,哈尔滨,151000 |
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| 摘 要： | 目的观察注射用洋参生脉粉针(YSSM)对急性心肌缺血的保护作用。方法分别采用垂体后叶素、异丙肾上腺素致大鼠急性心肌缺血模型,研究注射用洋参生脉粉针对急性心肌缺血模型大鼠心电图及血清生化指标的影响。结果YSSM(2.0、1.0、0.5 g.kg-1)能够抑制舌静脉注射垂体后叶素后所致的T波高耸(P<0.05,P<0.01);能够降低皮下注射异丙肾上腺素所致的∑ST段的升高程度(P<0.01,P<0.001);亦能够降低皮下注射异丙肾上腺素所致的急性心肌缺血模型大鼠血清中的心肌三酶AST、LDH、CK及CK-MB的活力(P<0.01,P<0.001)。结论注射用洋参生脉粉针(YSSM)对急性心肌缺血具有一定的保护作用。
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| 关 键 词： | 注射用洋参生脉粉针 心肌缺血 垂体后叶素 异丙肾上腺素 心肌酶 |
| 文章编号： | 1006-2858（2007）08-0508-04 |
| 修稿时间： | 2007-01-18 |
Protection effect of YSSM on acute myocardial ischemia |
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| LI Huan,ZHOU Xiao-mian,ZHANG Lin,WANG Yu-shu,CAO Ying-lin.Protection effect of YSSM on acute myocardial ischemia[J].Journal of Shenyang Pharmaceutical University,2007,24(8):508-511. |
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| Authors: | LI Huan ZHOU Xiao-mian ZHANG Lin WANG Yu-shu CAO Ying-lin |
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| Institution: | 1. School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China ; 2. Pharmaceutical Preparation Section, Heilongjiang Traditional Chinese Medicine Hospital, Harbin 151000, China |
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| Abstract: | Objective To observe the protection effect of Yangshenshengmai freeze-dried powder(YSSM,traditional Chinese medicines) on acute myocardial ischemia.Methods Using the acute myocardial ischemia model of rats subjected to Pit and Iso,the effects of YSSM on ECG and the biochemical indicator in blood serum in myocardial ischemia rats were inveseigated.Results At the dose of 6.4,3.2,1.6 g·kg-1,YSSM could markedly degrade the height of T wave(P<0.05,P<0.01)after injecting Pit through lingual vein,and could significantly degrade the increasing level of ∑ST(P<0.01,P<0.001)through hypodermic injection of Iso and degrade the myocardial enzymes(AST,LDH,CK and CK-MB)activity of blood serum in acute myocardial ischemia rats(P<0.01,P<0.001).Conclusions YSSM have the effect of anti-myocardial ischemia. |
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| Keywords: | Yangshenshengmai freeze-dried power(YSSM) myocardial ischemia pituitrin isoprenaline myocardial enzymes |
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