Fetuin—A与2型糖尿病患者动脉粥样硬化的相关性

目的：探讨胎球蛋白-A（fetuin—A，FA）与2型糖尿病患者动脉粥样硬化的相关性。方法：将60例糖尿病患者按颈动脉内膜中膜厚度（IMT）分为2组，糖尿病伴动脉粥样硬化组33例，IMT≥0．9mm，或有1个以上动脉粥样硬化斑块；糖尿病不伴动脉粥样硬化组27例，IMT〈0．9mm，无动脉粥样硬化斑块。另设正常对照组（20例）。所有对象均测定FA、IMT。结果：糖尿病两组FA值较正常对照组增高，差异均有统计学意义（P〈0．05）；糖尿病伴动脉粥样硬化组FA值高于糖尿病不伴动脉粥样硬化组，差异有统计学意义（P〈0．05）。两组FA值与IMT呈正相关。结论：FA在糖尿病动脉粥样硬化患者血清中显著升高，可作为糖尿病动脉粥样硬化的监测指标。

Relationship between fetuin-A and atherosclerosis in type 2 diabetes mellitus

Objective： To explore the relationship between fetuin-A and atherosclerosis in type 2 diabetes mellitus. Methods： 60 diabetic patients detected by carotid artery intima- media thickness（IMT）were divided into two groups： 33 diabetic cases with atherosclerosis group, IMT≥0.9 mm, or with more than one atherosclerotic plaque;27 diabetic cases without atherosclerosis group, IMT 〈 0.9 mm; 20 cases of normal control group. The levels of serum fetuin-A, IMT were measured in all subjects. Results： Fetuin-A values was significantly higher in diabetic group compared with the control group （ P 〈 0. 001 ）, fetuin- A values of diabetes with atherosclerosis group was higher than those of diabetes without atherosclerosis, and fetuin- A increased positively with IMT. Conclusion： Fetuin-A level in diabetic patients is significantly increased, and closely related to IMT values. Fetuin-A determination can be used as an indicator for monitoring, atherosclerosis in diabetes patients.