癫癎发作期PET定位药物难治性癫癎1例并文献复习 |
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引用本文: | 吴朝晖,赵全军,梁英魁,张剑宁,倪伟刚,赵虎林,王福莉,赵文锐,田增民.癫癎发作期PET定位药物难治性癫癎1例并文献复习[J].临床神经电生理学杂志,2014,23(6):342-344. |
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作者姓名: | 吴朝晖 赵全军 梁英魁 张剑宁 倪伟刚 赵虎林 王福莉 赵文锐 田增民 |
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作者单位: | 中国人民解放军海军总医院中国人民解放军微创神经外科研究所,北京,100048 |
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摘 要: | 目的:探讨药物难治性癫癎患儿在注射18F-DG药物时发生癫癎发作后所查正电子发射断层扫描(PET)显示局灶性高代谢灶的意义,并复习相关文献。方法:1例1岁零2个月女性患儿有发作性抽搐伴意识丧失13个月,智能发育落后于正常同龄儿童,视频脑电图显示左颁局限性癎样放电,MRI显示左侧颁叶局灶病变,在注射18F-DG药物时发生癫癎发作,斯时所查PET-CT显示左颁局灶性高代谢灶,因为与无创检查结果定位一致,遂行左侧颁叶后部癎灶切除术加中央前回软脑膜下横纤维切断术。结果:术前服用抗癫癎药物状态下每日发作数10次,术后6个月患儿癫癎完全缓解,切除组织病理学提示局灶性皮质发育不良(FCDIIb),手术后13d视频脑电图正常,6个月脑电图左侧额区尖波。患儿手术后6个月时智力有所进步,但仍落后于正常同龄儿。有文献显示在癫癎发作期注射18F-DG后PET在局灶性癫痂患者中一般显示局灶高代谢灶,并能定位政癎灶。结论:癫癎发作期注射18F-DGPET所显示的局灶高代谢区对致癎灶定位有很大帮助。
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关 键 词: | 癫癎 正电子发射断层扫描(PET) 药物难治性癫癎 致痂灶 局灶性皮质发育不良 (FCD) |
A case analysis of ictal PET to locate the epileptogenic zone and literature review |
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Institution: | WU Zhaohui, ZHAO Quanjun, LIANG Yingkui, et al (Navy General Hospital of People's Liberation Army, Beij ing(100048 ) , China) |
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Abstract: | Objective: To investigate the value of ictal PET-CT to locate the epileptogenic zone while epileptic seizure occurred at the time of 18F-DG injection, and to review the relative literature. Methods:A female child of one year and two month with intractable epilepsy and cerebrum dysplasia un- derwent an epileptic foci resection and multiple subpial transection with the V-EEG and MRI,and ictal PET abnormality was found on the left frontal area. Results:Before operation,the patient with antiepilep- tic drug had frequently epileptic seazures. After operation, the patient had not epileptic seazure within 6 months. The literature suggests that patients with focal epilepsy usually have focal high metablic zone on 18F-DG PET imaging. Conclusion ; The focal high metablic zone on ictal PET can help locate the epilepto- genic zone. |
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Keywords: | ictal PET intractable epilepsy epileptogenic zone focal cortical dysplasia |
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