| 空心莲子草总皂苷对D-半乳糖胺肝损伤的保护作用 |
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| 引用本文： | 樊一桥,武谦虎,洪敏,徐文强. 空心莲子草总皂苷对D-半乳糖胺肝损伤的保护作用[J]. 药学与临床研究, 2006, 14(3): 156-158 |
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| 作者姓名： | 樊一桥 武谦虎 洪敏 徐文强 |
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| 作者单位： | 中国药科大学镇江校区,镇江,212003;镇江市第三人民医院,镇江,212003;南京中医药大学,南京,210029 |
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| 基金项目： | 江苏省中医药局科研项目 |
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| 摘 要： | 目的通过实验考察空心莲子草总皂苷对小鼠化学性肝损伤的保护作用。方法采用D-半乳糖胺制备肝损伤小鼠模型。测定各组动物血清中丙氨酸氨基转移酶(ALT)、天门冬氨酸氨基转移酶(AST)的活性和肝脏丙二醛(MDA)的含量,并取肝脏作病理组织学检查。结果空心莲子草总皂苷可降低损伤小鼠血清ALT、AST的活性和MDA的含量。结论空心莲子草总皂苷对小鼠化学性肝损伤有一定的保护作用。
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| 关 键 词： | 空心莲子草总皂苷 D-半乳糖胺 肝损伤 肝保护 |
| 文章编号： | 1007-306(2006)03-156-03 |
| 修稿时间： | 2005-10-07 |
The Protection Effect of Total Sponin of Altemanthera philoxeroides on Mice Liver Damage Induced by D-GlaN |
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| FAN Yi-qiao,WU Qian-Hu,HONG Ming,XU Wen-qiang. The Protection Effect of Total Sponin of Altemanthera philoxeroides on Mice Liver Damage Induced by D-GlaN[J]. Pharmacertical and Clinical Research, 2006, 14(3): 156-158 |
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| Authors: | FAN Yi-qiao WU Qian-Hu HONG Ming XU Wen-qiang |
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| Abstract: | AIM To investigate the influence of total saponin of Altemanthera philoxeroides on mice liver damage induced by D-GlaN.METHOD The model of mice damage induced by 5% D-GlaN were used.The activity of serum alnine aminotransferase(ALT),serum aspartate aminotransferase(AST) and the quanity MDA were measured.The changes of the liver pathological were observed.RESULT The activity of ALT,AST and the quantity of MDA in the model group were reduced by total saponin of Altemanthera philoxeroides.CONCLUSION This experiment showed that the total saponin of Altemanthera philoxeroides had effect in protecting liver damage by chemical. |
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| Keywords: | Altemanthera philoxeroides Saponin D-GlaN Liver damage Liver protection |
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