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| 生物体内一氧化氮的检测方法及其应用 | |
| 引用本文： | 定天明,陈坚,张正行,张奕华. 生物体内一氧化氮的检测方法及其应用[J]. 药学进展, 2005, 29(5): 221-226 |
| 作者姓名： | 定天明 陈坚 张正行 张奕华 |
| 作者单位： | 1. 中国药科大学药学院药物分析教研室,江苏,南京,210009 2. 新疆医科大学药学院,新疆,乌鲁木齐,830054 3. 中国药科大学新药研究中心,江苏,南京,210009 |
| 基金项目： | 国家自然科学基金项目 ( 30 2 71 4 91 )，江苏省自然科学基金项目 (BK2 0 0 2 1 1 9) |
| 摘 要： | 简述一氧化氮的生物合成，重点介绍近年来生物体内一氧化氮的检测方法，如电化学法、化学发光法、分光光度法、荧光法、ESR波谱法及光纤化学(生物)传感技术等的研究与应用。在生物体内，一氧化氮具有重要的生物学意义，发挥着广泛的生理学、病理学和药理学作用，在体内测定其含量有助于推动对一氧化氮在医药学领域的应用研究。 |
| 关 键 词： | 一氧化氮 含量检测 体内 |
| 文章编号： | 1001-5094(2005)04-0221-06 |
| 修稿时间： | 2004-10-14 |
The Methods for Determination of Nitric Oxide in Vivo and Their Applications |
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| DING Tian-ming,CHEN Jian,ZHANG Zheng-xing,ZHANG Yi-hua. The Methods for Determination of Nitric Oxide in Vivo and Their Applications[J]. Progress in Pharmaceutical Sciences, 2005, 29(5): 221-226 | |
| Authors: | DING Tian-ming CHEN Jian ZHANG Zheng-xing ZHANG Yi-hua |
| Affiliation: | DING Tian-ming 1,CHEN Jian 2,ZHANG Zheng-xing 1*,ZHANG Yi-hua 3 |
| Abstract: | Nitric oxide (NO) plays an important role in physiology, pathophysiology and pharmacology of organism. The determination of NO in vivo is helpful for its research in pharmaceutical field. The biosynthesis of NO was briefly introduced. The methods of determination of NO, such as electrochemistry, chemiluminescence, fluorescence, spectroscopic, electron spin resonance (ESR) spectroscopy and optical-fiber chemical (biological) sensors were emphatically reviewed, and the applications of these methods in recent years were also discussed. |
| Keywords: | Nitric oxide Determination in vivo |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |