| 丹参与甲基泼尼松龙联用对急性肺损伤大鼠肺组织水通道蛋白-1表达的影响 |
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| 引用本文： | 程青,唐忠志,陈忠庆,李军尧,王忠强,邬明,郭亮.丹参与甲基泼尼松龙联用对急性肺损伤大鼠肺组织水通道蛋白-1表达的影响[J].实用医学杂志,2010,26(3). |
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| 作者姓名： | 程青 唐忠志 陈忠庆 李军尧 王忠强 邬明 郭亮 |
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| 作者单位： | 广州军区武汉总医院急诊科,430070 |
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| 摘 要： | 目的:观察联合应用丹参和甲基泼尼松龙对急性肺损伤(AII)大鼠肺组织水通道蛋白-l(AQP-1)表达的影响及其机制.方法:使用内毒素(LPS)3 mg/kg气管内滴入建立大鼠LPS吸入性ALI模型.50只大鼠随机分为:生理盐水对照组、LPS损伤组、甲基泼尼松龙组(LPS+甲基泼尼松龙)、丹参组(LPS+丹参)、联合用药组(LPS+甲基泼尼松龙+丹参).观察支气管肺泡灌洗液(BALF)中蛋白含量、肺组织湿/干重(W/D)比、肺脏病理改变,免疫组化法测定AQP-1表达.结果:经气管滴入LPS可致大鼠发生ALI.与LPS损伤组相比,单用甲基泼尼松龙或丹参组BALF中蛋白含量、肺组织W/D比值均明显降低(P＜0.01),肺组织AQP-1表达则明显升高(P＜0.01),以联合用药组更为明显(P＜0.01).结论:联合应用甲基泼尼松龙和丹参对ALI大鼠具有良好的治疗作用,其机制可能与促进肺组织AQP-1高表达有关.
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| 关 键 词： | 呼吸窘迫综合征 成人 丹参 甲基泼尼松龙 水通道蛋白-1 |
Effects of combined radix salviae miltiorrhizae and methylprednisolone on aquaporin-1 expression in lung tissues of rats with acute lung injury |
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| CHENG Qing,TA NG Zhong-zhi,CHEN Zhong-qing,LI Jun-yao,WANG Zhong-qiang,WU Ming,GUO Liang.Effects of combined radix salviae miltiorrhizae and methylprednisolone on aquaporin-1 expression in lung tissues of rats with acute lung injury[J].The Journal of Practical Medicine,2010,26(3). |
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| Authors: | CHENG Qing TA NG Zhong-zhi CHEN Zhong-qing LI Jun-yao WANG Zhong-qiang WU Ming GUO Liang |
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| Institution: | CHENG Qing,TANG Zhong-zhi,CHEN Zhong-qing,LI Jun-yao,WANG Zhong-qiang,WU Ming,GUO Liang.Department of Emergency,Wuhan General Hospital of Guangzhou Comm,,Wuhan 430070,China |
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| Abstract: | Objective To investigate the effects and mechanism of combined radix salviae miltiorrhizae(RSM) and methylprednisolone on aquaporin-1(AQP-1) expressions in lung tissues of rats with acute lung injury.Methods ALI models were induced by intratracheal instillation of LPS(3 mg /kg).Fifty rats were randomly divided into five groups:normal saline group as control,LPS group,methylprednisolone group(LPS + methylprednisolone),RSM group(LPS + RSM) and combined drug group(LPS + RSM + methylprednisolone).Protein conten... |
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| Keywords: | Respiratory distress syndrome adult Radix salviae miltiorrhizae Methylprednisolone Aquaporin-1 |
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