| 卵巢切除对大鼠骨组织结构改变的影响 |
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| 引用本文： | 程云英,贠红岩.卵巢切除对大鼠骨组织结构改变的影响[J].临床与实验病理学杂志,2000,16(5):400-402. |
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| 作者姓名： | 程云英 贠红岩 |
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| 作者单位： | 南京铁道医学院附院妇产科,210009 |
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| 摘 要： | 目的：探讨卵巢切除对大鼠骨组织形态学改变的影响。方法：将１８只３月龄雌性大鼠随机分为卵巢切除组及假手术组（对照组）。术后３周处死两组大鼠，获取股骨远端１／３处骨，分别进行石蜡包埋，塑料包埋切片及扫描电镜观察。结果：卵巢切除可引起大鼠骨小梁变细、中断，骨小梁表面钙盐沉积减少。结论：卵巢切除可使大鼠骨吸收增加，影响骨的稳定性，增加骨折发生的危险性。
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| 关 键 词： | 卵巢切除术 骨吸收 骨质疏松 绝经后 |
| 修稿时间： | 1999-07-14 |
Effect of ovariectomy on bone histomorphology in rats |
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| Cheng Yunying,Yong Hongyan.Effect of ovariectomy on bone histomorphology in rats[J].Chinese Journal of Clinical and Experimental Pathology,2000,16(5):400-402. |
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| Authors: | Cheng Yunying Yong Hongyan |
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| Abstract: | Purpose To determine the effect the ovariectomy on bone histomorphology in rats. Methods Eighteen female SD rats were randomly allocated into two groups:ovariectomy(OVX) group and sham operation(sham) group. The rats in both groups were killed three weeks after operation. One third of distal femur of the rats were taken out and processed with prarffin and plastic embedding and observed scanning electon microscope. Results Ovariectomy caused attenuation and interuption in trabeculae of bone and reduced mineral deposition on the trabacular surface. Conclusion Ovariectomy can increase bone absorbtion of the rats, affect the bone stability and increase the risk of fracture. |
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| Keywords: | ovariectomy absorbtion trabecular bone osteoporosis postmenopausal |
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