| 蝮蛇中抗血小板聚集多肽的纯化及其特征研究 |
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| 引用本文： | 徐伟,吴少瑜,张嘉杰,李志琴,吴曙光. 蝮蛇中抗血小板聚集多肽的纯化及其特征研究[J]. 中药材, 2004, 27(12): 914-915 |
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| 作者姓名： | 徐伟 吴少瑜 张嘉杰 李志琴 吴曙光 |
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| 作者单位： | 南方医科大学药物研究所,广东省新药筛选重点实验室,广州,510515 |
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| 摘 要： | 本实验采用高效液相C18层析柱,从华南地区产蝮蛇蛇毒中分离出一种分子量为23339.00Da的多肽SV-PP-2.SV-PP-2在体外能剂量依赖性地抑制ADP诱导的兔血小板聚集.在蝮蛇中尚未见有与SV-PP-2分子量相同并具有抑制血小板聚集作用的类似多肽的报道.
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| 关 键 词： | 蝮蛇蛇毒 血小板聚集 小分子肽 |
| 修稿时间： | 2004-09-29 |
Purification and Characteristics of Polypeptide with Inhibition of Platelet Aggregation from Agkistrodon blomhoffii Bioe |
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| Xu Wei,Wu Shaoyu,Zhang Jiajie,Li Zhiqin,Wu Shuguang. Purification and Characteristics of Polypeptide with Inhibition of Platelet Aggregation from Agkistrodon blomhoffii Bioe[J]. Journal of Chinese medicinal materials, 2004, 27(12): 914-915 |
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| Authors: | Xu Wei Wu Shaoyu Zhang Jiajie Li Zhiqin Wu Shuguang |
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| Affiliation: | Guangdong Key Lab for Drug Screening, Nanfang Medical University, Guangzhou. |
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| Abstract: | A polypeptide,SV-PP-2,was purified from Agkistrodon blomhoffii Bioe by HPLC C 18 column The SV-PP-2 has molecular weight of 23339 00Da,and can inhibit the ADP-induced platelet aggregation in dose-dependent manner There have been no such polypeptides reported yet which has inhibition of platelet aggregation and similar molecular weihgt to SV-PP-2 |
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| Keywords: | Snake venom Platelet aggregation Peptide |
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