| 枫香油对5种药物离体大鼠皮肤渗透的促进作用 |
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| 引用本文： | 李蓓,徐惠南,翁伟宇,沈杰,张峰. 枫香油对5种药物离体大鼠皮肤渗透的促进作用[J]. 复旦学报(医学版), 1998, 0(5) |
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| 作者姓名： | 李蓓 徐惠南 翁伟宇 沈杰 张峰 |
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| 作者单位： | 上海医科大学药学院药剂学教研室 |
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| 摘 要： | 目的研究自制枫香油对双氯灭痛、甲硝唑、甲氧氯普胺、川芎嗪和沙丁胺醇等５种药物的透皮促进作用。方法采用Ｖ－Ｃ水平扩散池，以紫外、比色和ＨＰＬＣ法测定药物通过离体大鼠腹部皮肤的渗透系数。结果枫香油均使５种药物的渗透系数增大。除沙丁胺醇外，对其他４种药物的透皮促进作用均优于ａｚｏｎｅ。结论枫香油对药物透皮扩散有明显的促进作用
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| 关 键 词： | 挥发油；枫香树脂；促透作用 |
ENHANCEMENT OF SKIN PENETRATION BY VOLATILE OIL OF RESINA LIQUIDAMBARIS |
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| Li Pei,Xu Huinan,Weng Weiyu,Shen Jie,Zhang Feng. ENHANCEMENT OF SKIN PENETRATION BY VOLATILE OIL OF RESINA LIQUIDAMBARIS[J]. Fudan University Journal of Medical Sciences, 1998, 0(5) |
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| Authors: | Li Pei Xu Huinan Weng Weiyu Shen Jie Zhang Feng |
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| Abstract: | PURPOSE To study the skin penetration enhancement of volatile oil of Resina liquidambaris (VORL) for the first time. METHODS The enhancing ability of VORL through the intact rat skin in vitro was studied using diclofenac, metronidazole, metoclopramide, salbutamol and tetramethylpyrazine as model drugs and azone as reference. RESULTS It was found that VORL could increase the permeability of these five drugs through the intact rat skins. The enhancing ability of VORL was greater than that of azone with the exception of salbutamol. The mixture of VORL and propylene-glycol didn't show any cooperation effects. CONCLUSIONS The results suggeste that VORL is an excellent transdermal penetrater. It is worthy for further study. |
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| Keywords: | volatile oil Resina liquidambaris transdermal enhancing effect |
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