氯沙坦治疗老年性高血压伴高尿酸血症的临床研究

目的：探讨氯沙坦对老年高血压伴高尿酸血症患者的降压和降尿酸作用。方法：60例老年高血压合并高尿酸血症患者随机分成2组，氯沙坦组30例，每天口服氯沙坦50mg，卡托普利组30例，每天口服卡托普利25mg，药物剂量根据血压水平调整，治疗4周，测定2组治疗前、后收缩压、舒张压、血清尿酸水平．并对2组进行了比较。结果：（1）2组治疗后收缩压、舒张压均较治疗前明显下降（P〈0．05），2组组间治疗后比较差异无统计学意义（P〉0．05）；（2）治疗后氯沙坦组血清尿酸水平较治疗前明显下降（P〈0．05），而卡托普利组无明显变化（P〉0．05）；（3）氯沙坦组头晕1例（3．3％），卡托普利组咳嗽4例（13．3％）。结论：氯沙坦可降低老年高血压合并高尿酸血症患者血压和血清尿酸水平，合并高尿酸血症的老年高血压病人可安全选用氯沙坦。

Therapeutic effect of losantan on hypertension associated with hyperuricemia in elderly patients

Objective: To study the effects of treating uricacidemia and anti-hypertension by losartan in elderly patients with hypertension associated hyperuricemia. Methods: Selected 60 elderly patients with hypertension and hyperuricemia, in which divided two groups by random, one group with losartan 50 mg per day po, other group with captopril 25 mg per day po, the drug dose can be changed according the level of the blood pressure, for 4 weeks, compared the changes of serum uric acid and the blood pressure for two groups. Results: (1) The systolic blood pressure and diastolic blood pressure decreased prominently in both groups after four weeks treament (P <0. 05) , but there was no significant difference between losartan group and captopril group (P >0. 05); (2) The serum uric acid had apparently reduced in losartan group after four weeks treatment (P <0. 05), while there was not significantly reduced in captopril group (P >0. 05); (3) There was no significant side-effect between losartan group and captopril group. Conclusions: Losartan can drecrease the level of the blood pressure and serum uric acid, which is effective and safe for elderly essential hypertension patients with hyperuricemia using losartan to control the blood pressure.